Toxic effects of MDMA on brain serotonin neurons. Lancet 1999;353:1269-70.Klugman A, Hardy S, Baldeweg T, Gruzelier J (1999) Toxic effect of MDMA on brain serotonin neurons. Lancet 353: 1269-1270.J.F. Morgan, Toxic effect of MDMA on brain serotonin neurons, Lancet 353 (1999) 1268-...
Its primary effects are in the brain on neurons that use the chemical serotonin to communicate with other neurons. The serotonin system plays an important role in regulating mood, aggression, sexual activity, sleep, and sensitivity to pain.
MDMA stimulates the release of neurotransmitters, such as serotonin and norepinephrine, from brain neurons producing a high that lasts from 3 to 6 hours, but the length of a high is variable based on the user. The drug's rewarding effects vary with the individual taking it, the dose taken,...
As an amphetamine, MDMA increases activity in three of the brain’s neurotransmitters: dopamine, serotonin and norepinephrine. The biggest effect is on serotonin, which regulates anxiety, happiness and mood. The artificially increased production results in the “high” that users experience, including...
(Meissner et al., 2001). Yet, at low dose the effect of these four compounds on serotonin redistribution was transient, and did not induce cell death. Therefore, while blocking theserotonin transporterappears to be sufficient to alter the intracellular distribution of serotonin, this by itself ...
Positron emission tomographic evidence of toxic effect of MDMA ("Ecstasy") on brain serotonin neurons in human beings. 3,4-Methylenedioxymethamphetamine (MDMA, “Ecstasy”) Induces Fenfluramine-Like Proliferative Actions on Human Cardiac Valvular Inte... ...
增强LSD、赛洛西宾或其他致幻剂的急性情绪效应特征的MDMA治疗.pdf,披露了一种增强致幻剂的积极效应的方法,该方法为:用神入感激发剂/放心药诱导个体的积极心理状态,向个体施用致幻剂,并增强对致幻剂的积极反应。一种包含放心药/神入感激发剂和5‑羟色胺能致幻剂的组合
Another related phenomenon is tolerance, a gradual decrease in the effect of a certain dose as the drug is repeatedly taken; increasingly larger doses are needed to produce the desired effect. Tolerance does not always develop. It is most marked with habitual opiate users. The term addiction is...
Classification of psychedelics and psychoactive drugs based on brain-wide imaging of cellular c-Fos expression Farid Aboharb Pasha A. Davoudian Alex C. Kwan Nature Communications (2025) Shrinking the know–do gap in psychedelic-assisted therapy Ginger E. Nicol Danielle R. Adams Leopoldo J. ...
Positron emission tomographic evi dence of toxic effect of MDMA (ecstasy) on brain serotonin neurons in human beings. Lancet 1998; 352: 1433-1437. 22. Redfearn P J, Agrawal N, Mair L H. An association between the regular use of 3,4 methylenedioxy methamphetamine (ecstasy) and ...