MDMA stimulates the release of neurotransmitters, such as serotonin and norepinephrine, from brain neurons producing a high that lasts from 3 to 6 hours, but the length of a high is variable based on the user. The drug's rewarding effects vary with the individual taking it, the dose taken,...
Toxic effect of MDMA on brain serotonin neurons. Lancet 1999;353:1268 -1271Morgan JF. Toxic effect of MDMA on brain serotonin neurons. Lancet. 1999;353: 1268-1269.Klugman A, Hardy S, Baldeweg T, Gruzelier J: Toxic effect of MDMA on brain serotonin neurons. Lancet 1999; 353:1269- ...
Its primary effects are in the brain on neurons that use the chemical serotonin to communicate with other neurons. The serotonin system plays an important role in regulating mood, aggression, sexual activity, sleep, and sensitivity to pain.
said: “Nearly half a million people are believed to take ecstasy every year in the UK, but there has been very little research into what it does in the brain. This is the first study that will involve brain scans of people taking MDMA while...
(±)3,4-methylenedioxymethamphetamine (MDMA, “Ecstasy”) is a popular recreational drug that selectively damages brain serotonin (5-HT) neurons in animals at doses that closely approach those used by humans. We investigated the status of brain 5-HT neurons in MDMA users. Methods We enrolled ...
Positron emission tomographic evidence of toxic effect of MDMA ("Ecstasy") on brain serotonin neurons in human beings. 3,4-Methylenedioxymethamphetamine (MDMA, “Ecstasy”) Induces Fenfluramine-Like Proliferative Actions on Human Cardiac Valvular Inte... ...
Positron emission tomographic evidence of toxic effect of MDMA (“Ecstasy”) on brain serotonin neurons in human beings SummaryBackground (±)3,4-methylenedioxymethamphetamine (MDMA, “Ecstasy”) is a popular recreational drug that selectively damages brain serotonin (5-HT) ... MCSSD Ricaurte - ...
As we wanted to begin to address the question of the effect of low-dose MDMA on brain function, our study enrolled individuals having between 3 and 155 episodes of MDMA use and, therefore, included individuals with very-low MDMA exposure levels. A simple average of the means or a ...
The frequency and degree of long-term adverse effect on the human brain and mental function remains unknown, but in view of widespread and continuing illegal distribution, both acute and chronic effects of this drug deserve further research. 展开 ...
(Meissner et al., 2001). Yet, at low dose the effect of these four compounds on serotonin redistribution was transient, and did not induce cell death. Therefore, while blocking theserotonin transporterappears to be sufficient to alter the intracellular distribution of serotonin, this by itself ...