SummaryBackground (±)3,4-methylenedioxymethamphetamine (MDMA, “Ecstasy”) is a popular recreational drug that selectively damages brain serotonin (5-HT) ... MCSSD Ricaurte - 《Lancet》 被引量: 1153发表: 1998年 Substance use and risky sexual behavior for exposure to HIV. Issues in methodology...
Background The recreational use of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) among adolescents and young adults has become increasingly prevalent i... GM Modi,PB Yang,AC Swann,... - 《Behavioral & Brain Functions》 被引量: 101发表: 2006年 ...
Post-traumatic stress disorder (PTSD) presents a major public health problem for which currently available treatments are modestly effective. We report the findings of a randomized, double-blind, placebo-controlled, multi-site phase 3 clinical trial (NCT03537014) to test the efficacy and safety of ...
In the present study we have investigated the long-term effects of administering increasing doses of delta-9-tetrahydrocannabinol [THC; 2.5, 5, 10 mg/kg; i.p.] from postnatal day (pnd) 28 to 45, alone and/or in conjunction with 3,4-methylenedioxymethamphetamine [MDMA; two daily doses ...
Candy flipping, the combination of LSD (lysergic acid diethylamide) and MDMA (methylenedioxymethamphetamine), involves the use of two powerful psychoactive substances known for their hallucinogenic and mood-enhancing effects. This practice is popular amo
As they say “one day at a time” and perhaps we could extend that advise to “one lifetime at a time”. The feeling of loneliness is likely the result of mixing deep brain circuits evolved to track things like one’s place in the tribe via feelings of belongingness and togetherness, ...
(PET) scans in baboons showed significant decreases in radioactivity levels in various brain areas. Similarly, human volunteers with a history of MDMA use underwent PET scanning and were found to have a global dose-related reduction in a structural element of serotonin. Further studies on PET ...
How MDMA works in the brain is not completely understood. Thepsychoactive drugboosts chemicals likeserotoninand oxytocin. It also tamps down activity in the amygdala, a part of the brain that processes fear. This may lead to a state characterized by heightened feelings of safety and social conne...
MDMA and Brain Activity 12 Neuroendocrine Effects of MDMA 13 Immunological Effects of MDMA 13 Behavioral and psychological effects 13 Humans 14 3. Pharmacokinetics and biological disposition 16 4. Safety and effectiveness in humans obtained from prior clinical studies 17 MDMA-assisted psychotherapy for ...
Pickedupthename“ecstasy”&becamesignificantstreetdrug(1980s)•ScheduleIdrug(1986-TheAnaloguedrugAct)•Prototype“clubdrug”(1990s)MDMA:PrototypeClubDrugPharmacodynamicsPharmacodynamicsMonoamineneurotransmission–increasesynapticDAand5-HT–blocks5-HTtransporter–entersneuronandcausesreleaseof5-HTEcstasyandbrainDamage...