miRNAoropharyngeal cancerAs mouse double minute 4 (MDM4) and HPV16 E6 oncoproteins play important roles in inhibition of p53 activity, a functional polymorphism (rs4245739) in the 3′ untranslated regions of MDM4 targeted by microRNA1 may alter its expression level or functional efficiency, thus ...
刚刚,诺贝尔基金会宣布,麻省大学医学院的Victor Ambros、麻省总医院的Gary Ruvkun获得2024年诺贝尔生理学或医学奖,获奖理由为他们在microRNAs(一组称为微小RNA,miRNA)方面的突出贡献,获奖者主要针对秀丽线虫中的microRNAs进行研究。 近几年来,miRNA的小分子成为...
研究通过临床试验证实,金银花汤剂中的miRNA可通过饮用被人体有效吸收,并在体内有效抑制新冠病毒复制,加速新冠患者转阴,表明金银花汤剂治疗可能会极大地帮助治愈新冠患者并阻止COVID-19大流行。 该研究通讯作者为南京大学生命科学学院教授张辰宇、中科院武汉...
miRNAoropharyngeal cancerAs mouse double minute 4 (MDM4) and HPV16 E6 oncoproteins play important roles in inhibition of p53 activity, a functional polymorphism (rs4245739) in the 3′ untranslated regions of MDM4 targeted by microRNA‐191 may alter its expression level or functional efficiency, ...
Variation of the breast cancer susceptibility marker, rs4245739, is associated with differential miRNA binding and MDM4 expressionA polymorphism, rs4245739, has been associated with susceptibility of several cancers including ER-negative breast cancer. Rs4245739 is located at the 3'UTR of MDM4 gene,...
MDM4 regulation by the let-7 miRNA family in the DNA damage response of glioma cells. FEBS Lett 2015;589:1958-65.Xie C, Chen W, Zhang M, Cai Q, Xu W, Li X, Jiang S. MDM4 regulation by the let-7 miRNA family in the DNA damage response of glioma cells. FEBS Lett. 2015; 589...