also receive psychotherapy or counseling, although the effectiveness of medication for mild or moderate cases is questionable. Hospitalization may be necessary in cases with associated self-neglect or a significant risk of harm to self or others. A minority are treated with electroconvulsive therapy (E...
Fortunately, hippocampal alterations may normalize as hippocampal enlargement has been observed following remission or treatment of MDD48,50,51. We also found smaller hippocampal volumes in patients with an adolescent onset of MDD (⩽21 years; ...
Case management for the treatment of patients with major depression in general practices – rationale, design and conduct of a cluster randomized controlle... p pBackground/p pDepression is a disorder with high prevalence in primary health care and a significant burden of illness. The delivery ...
In this paper, we present a mixed-method empirical investigation of applying MDD in the CMS domain, based on an interview suite, a controlled experiment, a field experiment, and case studies. During the experiments, we used JooMDD, an MDD infrastructure instantiation for CMS extensions. This ...
In this study, pain is divided in nociceptive pain and neuropathic pain and treatment of pain will be applied based on which of these two sorts of pain a patient has. Classification as nociceptive pain, neuropathic pain or mixed pain will be done with the PainDETECT questionnaire that was spec...
The present sample consists of richly phenotyped, individual-level data from participants with first episode or recurrent MDD, that is not treatment-resistant depression, antidepressant medication-free, with prospective longitudinal treatment outcomes, and healthy controls. The current focus is on ...
In this trial, we aim to improve depressive symptoms of patients with MDD with concomitant subchronic or chronic pain symptoms of nociceptive, neuropathic, mixed or functional nature. As discerning nociceptive pain from neuropathic pain may have therapeutic consequences in the treatment of (sub)chronic...
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