MDD is associated with a wide range of negative outcomes including: loss of occupational function [3], reduced quality-of-life [4], and premature mortality [5]. Whilst some may experience a single lifetime episode of MDD, it is becoming more widely recognised as a chronic condition, ...
The largest effect size was observed in the medial OFC, which—in contrast to lower hippocampal volume—was already detectable in first-episode patients. In contrast to the hippocampal volume finding that were driven by adult patients with an adolescent onset of their first depressive episode, the...
GAD 23 (16) 28.57 9.74 54.74⁎⁎⁎ 9.27 15.43⁎⁎⁎ 8.74 MDD 21 (14) 32.10 10.01 60.24⁎⁎⁎ 7.35 25.59⁎⁎⁎ 7.46 Current episode axis I DSM-IV-TR diagnoses were determined using the research version of the structured clinical interview for DSM-IV-TR (SCID) ...