As such, it is crucial to generate MDR1 and BCRP substrate data with a high fidelity. In this study, two widely use human MDR1 cell lines from Borst and NIH labs were evaluated using rodent brain penetration data, and the study suggested that the MDR1-MDCK cell line from NIH lab ...
It is of great challenge to predict human brain penetration for substrates of multidrug resistance protein 1 (MDR1) and/or breast cancer resistance protein (BCRP), two major efflux transporters at blood-brain barrier. Thus, a PBPK model with the incorporation of in vitro MDR1 and BCRP transpor...
P58 - Utilising a dual human transporter MDCK_MDR1_BCRP cell line to assess efflux at the blood brain barrierdoi:10.1016/j.dmpk.2020.04.059Dermot McGinnityNicola ColcloughRavindra AlluriDanxi LiYumei YanDrug Metabolism and Pharmacokinetics
Evaluation of Drug Transport in MDCKII-Wild Type, MDCKII-MDR1, MDCKII-BCRP and Caco-2 Cell LinesIntroductionPathophysiology of Hepatobiliary SystemInborn Errors of Bile Acid/Salt Transporter DeficienciesDrugs and Cholestatic Liver DiseasePhospholipases and PhospholipidosisMechanisms of Toxicity Associated ...