BRCA1分析表明这株细胞是BRCA1 5382C突变纯合的, 而来源于同一病人的类淋巴母细胞细胞株在这个突变位点上是杂合的。 另两个家庭成员也有这个突变; 一个同卵双生姐妹也患有乳腺癌。这株细胞有一个后天的TP53突变, 而其野生型等位基因丢失; 一个PTEN基因的后天的纯合缺失, 以及多个与乳腺癌发病机理相关的位点上...
BRCA1分析表明这株细胞是BRCA1 5382C突变纯合的, 而来源于同一病人的类淋巴母细胞细胞株在这个突变位点上是杂合的。 另两个家庭成员也有这个突变; 一个同卵双生姐妹也患有乳腺癌。这株细胞有一个后天的TP53突变, 而其野生型等位基因丢失; 一个PTEN基因的后天的纯合缺失, 以及多个与乳腺癌发病机理相关的位点上...
人肝癌细胞;Hep G2 [HepG2] 人靶向核糖核酸酶()ELISA 试剂盒 PALB2(partner and locaizer of BRCA2) 癌易感基因相关蛋白2 0.5mg MDA-MB-468人乳腺癌细胞RN-s, 大鼠纹状体神经元 大鼠补体片断3a(C3a)ELISA试剂盒 OPG(Human Osteoprotegerin) 人骨保护素 96T phospho-P (Ser153): 0酸化Raf激酶抑制蛋白...
(P<0.05);与shRNA-NC组比较,shRNA-BLM组细胞增殖能力被抑制,凋亡率升高,尾部DNA含量增加,γ-H2AX阳性细胞比例升高(P<0.01),凋亡相关蛋白Bax,cleaved Caspase-3,cleaved Caspase-8表达上调,Bcl-2及DNA损伤修复蛋白BRCA1,Rad51,BLM表达下调(P<0.05).结论沉默BLM DNA解旋酶基因表达抑制三阴性乳腺癌细胞增殖,促进...
cell line CAL-85-1 cell line VP303 Thawing SUM102PT Cells Evsa-T Adherent HDQ-P1 BC-019 human breast cancer cells SUM190PT Cells MDA-MB-157 cell line BC-025 Adherent MCF-7B BC-021 Adherent Human breast cancer susceptibility protein 1,BRCA-1 ELISA Kit Human breast cancer cell HS 578...
MDA-MB-468, BRCA1KD MCF10A, HCC1937 as in TNBBC panel showed effective killing when various combination of pAkt and PI3K, mTOR inhibitors, CDK1/2 inhibitors, death receptor mediated apoptosis inducing agents were introduced in combinat... B Lim,DT Dicker,LC Kline,... - 《Cancer Research...
Results: The results showed that mutated TP53 in MDA-MB-468 cells interacted with BRCA1 protein in vivo and did not effect WT TP53 binding to this protein in vitro. The Immunoprecipitation assays revealed that the mutated TP53 did not bind to RAD51 in comparison to WT TP53. However, this ...