Triple-negative breast cancerTriple-negative breast cancer (TNBC) shares the molecular features facilitating epithelial-to-mesenchymal transition (EMT), which contributed to tumor invasion and metastasis. A platinum(IV) conjugate ketoplatin deriving from FDA-approved drugs cisplatin and ketoprofen was ...
pHLIP‑P1AP在酸性环境下能够有效靶向MDA-MB-231细胞,并抑制MDA-MB-231细胞的生长,有望成为治疗TNBC的有价值的新型药物。 三阴性乳腺癌(triple-negative breast cancer, TNBC)是指雌激素受体(estrogen receptor, ER)、孕激素受体(progesterone receptor, PR)和表皮生长因子受体2(human epidermal growth factor recept...
[2]Patient-reported outcomes from the phase III IMpassion130 trial of atezolizumab plus nab-paclitaxel in metastatic triple-negative breast cancer[J].S.Adams,V.Diéras,C.H.Barrios,E.P.Winer,A.Schneeweiss,H.Iwata,S.Loi,S.Patel,V.Henschel,S.Y.Chui,H.S.Rugo,L.A.Emens,P.Schmid.Annals of...
本研究通过慢病毒沉默人基底样乳腺癌MDA-MB-231细胞的BRCA1,特异性抑制HRR过程,建立了沉默BRCA1(silencing BRCA1, shBRCA1)的MDA-MB-231乳腺癌裸鼠模型,并采用18F-FLT microPET/CT显像观察在体内实验中shBRCA1联合放疗对乳腺癌移...
近年来,乳腺癌的早期诊断和治疗虽然取得了较大进展,但大多数患者极易复发和转移,特别是三阴性乳腺癌(triple negative breast cancer,TNBC)患者。TNBC是一种雌激素受体(estrogen receptor,ER)、孕激素受体(progesterone receptor,PR)和人表皮生长...
三阴性乳腺癌(triple-negative breast cancer, TNBC)是一类缺乏雌激素受体、孕激素受体和人类表皮生长因子受体2的乳腺癌类型,约占全部乳腺癌的15%[1],具有较高的恶性程度和复发转移风险。放疗通过造成DNA单链或双链断裂,从而抑制肿瘤细胞生长。部分肿瘤细胞由于基因的改变可导致肿瘤细胞产生放疗抗性,从而降低疗效[2]。
英文名称: Human triple negative breast cancer MDA-MB-231 + luciferase 总访问: 623 国产/进口: 国产 半年访问: 14 产地/品牌: 雅吉生物 产品类别: 细胞株/菌种 规格: T25瓶/1*10^6 最后更新: 2025-1-2 货号: YS921C 参考报价: 1800 立即询价 电话咨询 ...
结论:MDA-MB-231细胞表面表达大量的PAR1。pHLIP‑P1AP在酸性环境下能够有效靶向MDA-MB-231细胞,并抑制MDA-MB-231细胞的生长,有望成为治疗TNBC的有价值的新型药物。 三阴性乳腺癌(triple-negative breast cancer, TNBC)是指雌激素受体(estrogen receptor, ER)、孕激素受体(progesterone receptor, PR)和表皮生长因子...
Moreover, expressions of miR-1246 were down- regulated in MB-231Brm, compared with MB-231. Therefore, miR-1246 may participate in the occurrence and development of TNBC brain metastasis. 【KEY WORDS】 triple negative breast cancer;brain metastasis;differentially expression;microRNA;miR-1246 乳腺癌...
土木香内酯(ALANTOLACTONE)是一倍半萜内酯,通过抑制STAT3信号转导和活化对三阴性乳腺癌MDA-MB-231细胞有抑制活性。CAS号: 英文名: ALANTOLACTONE is a sesquiterpene lactone that inhibits triple negative breast cancer MDA-MB-231 cells by inhibiting STAT3 signaling and activation....