The biopsy material of the present study was analyzed with qPCR technology to determine the mRNA expression of the genes encoding for nPRs, mPRs and PGRMCs. However, the observed changes in mRNA can, but may not, reflect expression of the respective proteins. Occurrence of translational and pos...
Our study suggests that hypoxia intervention was sufficient to induce the differentiation of Tbx18-positive epicardial cells to CoSMCs. Furthermore, this differentiation was achieved primarily via HIF-1α-mediated regulation of Snail. Coronary vascular smooth muscle cells (CoSMCs) provide structural ...