近期发现的MCM8和MCM9是MCM2-7复制解旋酶的旁系同源蛋白,与MCM2-7不同,MCM8和MCM9可以形成具有DNA解旋酶活性的复合物,其在DNA复制起始时不是必需的,但在有丝分裂和减数分裂细胞中都参与了同源重组。MCM8-9在同源重组早期和晚期...
结构显示,MCM8和MCM9先形成异源二聚体,三个MCM8/9二聚体通过三重对称组装成六聚体,中央形成一个直径为28 Å的通道,可以允许双链DNA通过。另外,与MCM2-7类似,MCM8/9也含有MCM解旋酶典型的loop结构,如OB hairpin loops, H2I, PS1等,这些loop在MCM8/9的解旋酶活性中发挥DNA双链的解旋作用。
Indeed, mice null for MCM9 have been created by John Schimenti's group. Instead of a role in DNA replication, MCM8-9 complex is required for repair of DNA interstrand crosslinks (ICLs) and Homologous Recombination (HR)-mediated repair of double-strand breaks (DSBs) at a stage prior to ...
2a, b, Table S1), suggesting that HORMAD1 might have a functional link with MCM8–MCM9 complex in cancer cells. Fig. 2: HORMAD1 interacts with MCM8-MCM9 complex. a 293T cells stably expressing either the vector control or SFB-tagged HORMAD1 were used for tandem affinity purification....
► Mcm8 and Mcm9 form a complex nonessential for DNA replication ► mcm8KO and mcm9KO cells are hypersensitive to ICL-inducing agents ► The Mcm8-9 complex functions downstream of the FA and BRCA2/Rad51 pathways ► The Mcm8-9 complex functions in HR repair, possibly as a hexamer...
Homologous recombination (HR) mediates the error-free repair of DNA double-strand breaks to maintain genomic stability. Here we characterize C17orf53/MCM8IP, an OB-fold containing protein that binds ssDNA, as a DNA repair factor involved in HR. MCM8IP-de
摘要: MCM8 and MCM9 knockout mice show defects in gametogenesis MCM8/ females develop ovarian tumors MCM8- and MCM9-deficiency impairs homologous recombination MCM8- MCM9-deficient cells are hypersensitive to DSBs and replication stress关键词: Ovary Germ Cells Spermatocytes Chromatin Fibrob...
北京商报讯(记者胡静蓉)8月19日,根据MCM发布的闭店函,MCM小红书官方旗舰店将于2024年9月16日正式闭店,即日起下架店铺商品。MCM方面表示,顾客仍可在其他线上及线下官方销售渠道选购MCM产品。北京商报记者看到,目前,该店铺仅剩4款... 网页链接
*与GCD10共享的5素非翻译区包含一个CpG岛和一个假定的CCAAT元件,该元件距离GCD10起始点不到30bp,但缺少任一基因的TATA框。 * MCM8基因存在LIR结构域,作为自噬受体与LC3结合。 如需了解更多关于MCM8基因结构的信息,建议咨询遗传学专家或查阅相关文献资料。©...
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