近期发现的MCM8和MCM9是MCM2-7复制解旋酶的旁系同源蛋白,与MCM2-7不同,MCM8和MCM9可以形成具有DNA解旋酶活性的复合物,其在DNA复制起始时不是必需的,但在有丝分裂和减数分裂细胞中都参与了同源重组。MCM8-9在同源重组早期和晚期...
结构显示,MCM8和MCM9先形成异源二聚体,三个MCM8/9二聚体通过三重对称组装成六聚体,中央形成一个直径为28 Å的通道,可以允许双链DNA通过。另外,与MCM2-7类似,MCM8/9也含有MCM解旋酶典型的loop结构,如OB hairpin loops, H2I,...
Finally, we showed that knocking out MCM9 increased the sensitivity of HCT116 xenograft tumors to cisplatin. Taken together, the data suggest that conceptual MCM8‐9 inhibitors will be powerful cancer‐specific chemosensitizers for platinum compounds and poly(ADP‐ribose) polymerase inhibitors, thereby...
Homologous recombination (HR) mediates the error-free repair of DNA double-strand breaks to maintain genomic stability. Here we characterize C17orf53/MCM8IP, an OB-fold containing protein that binds ssDNA, as a DNA repair factor involved in HR. MCM8IP-de
► Mcm8 and Mcm9 form a complex nonessential for DNA replication ► mcm8KO and mcm9KO cells are hypersensitive to ICL-inducing agents ► The Mcm8-9 complex functions downstream of the FA and BRCA2/Rad51 pathways ► The Mcm8-9 complex functions in HR repair, possibly as a hexamer...
Mcm8Mcm9and Xenopus laevishomologous recombinationThe CRISPR (clustered regularly interspaced short palindromic repeats)/Cas (CRISPR-associated) system of bacteria and archaea constitutes a mechanism of acquired adaptive immunity against phages, which is based on genome-encoded markers of previously ...
2a, b, Table S1), suggesting that HORMAD1 might have a functional link with MCM8–MCM9 complex in cancer cells. Fig. 2: HORMAD1 interacts with MCM8-MCM9 complex. a 293T cells stably expressing either the vector control or SFB-tagged HORMAD1 were used for tandem affinity purification....
*与GCD10共享的5素非翻译区包含一个CpG岛和一个假定的CCAAT元件,该元件距离GCD10起始点不到30bp,但缺少任一基因的TATA框。 * MCM8基因存在LIR结构域,作为自噬受体与LC3结合。 如需了解更多关于MCM8基因结构的信息,建议咨询遗传学专家或查阅相关文献资料。©...
苏宁易购为您提供MCMMWS9APA81RU001MWS8APA81BK001女士单肩包和MCM 女士Millie系列人造革手拿包单肩斜挎包小号 MWRAAME03参数对比,让您了解MCMMWS9APA81RU001MWS8APA81BK001女士单肩包和MCM 女士Millie系列人造革手拿包单肩斜挎包小号 MWRAAME03哪个好,让您选择更喜欢的商
北京商报讯(记者胡静蓉)8月19日,根据MCM发布的闭店函,MCM小红书官方旗舰店将于2024年9月16日正式闭店,即日起下架店铺商品。MCM方面表示,顾客仍可在其他线上及线下官方销售渠道选购MCM产品。北京商报记者看到,目前,该店铺仅剩4款... 网页链接