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EdgeR and DESeq2 tools were used to normalize gene expression and analyze gene significance. The volcano plot used the Omicsmart tool to describe all tested gene data. Cell counting kit-8 (CCK-8) assay CCK-8 assays were performed in 96-well plates, and the cells were treated as described...
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The Mini-chromosome maintenance (Mcm) proteins are essential as central components for the DNA unwinding machinery during eukaryotic DNA replication. DNA primase activity is required at the DNA replication fork to synthesize short RNA primers for DNA cha
Origin licensing ensures precise once per cell cycle replication in eukaryotic cells. The Origin Recognition Complex, Cdc6 and Cdt1 load Mcm2-7 helicase (MCM) into a double hexamer, bound around duplex DNA. The complex formed by ORC-Cdc6 bound to duplex
6220 Accesses 22 Citations 25 Altmetric Metrics details Abstract The controlled assembly of replication forks is critical for genome stability. The Dbf4-dependent Cdc7 kinase (DDK) initiates replisome assembly by phosphorylating the MCM2-7 replicative helicase at the N-terminal tails of Mcm2, Mcm4...
30. Goel S, DeCristo MJ, McAllister SS, Zhao JJ. CDK4/6 Inhibition in Cancer: Beyond Cell Cycle Arrest. Trends Cell Biol. 2018;28(11):911–25. https://doi. org/10.1016/j.tcb.2018.07.002 Epub 2018/08/01. PubMed PMID: 30061045; PMCID: PMC6689321. 31. Pucci B, Kasten M, ...
probablemente porque la aplicación “ya estaba aquí mucho antes que todos los miembros actuales de TI y nadie tiene documentación” (cualquier parecido con la realidad es mera coincidencia); entonces, tomas tu teclado, inicias sesión en tu controlador de dominio de confianza y abres Performan...
Homologous recombination (HR) mediates the error-free repair of DNA double-strand breaks to maintain genomic stability. Here we characterize C17orf53/MCM8IP, an OB-fold containing protein that binds ssDNA, as a DNA repair factor involved in HR. MCM8IP-de
This work was supported in part by a Grant from the Ministry of Education, Science, Sports and Culture of Japan.The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked “advertisement” in accordance with 18...