3b). Taken together, mitotic apoptosis in HeLa cells is triggered by MCL1 degradation that associates with the induction of BAK and BAX conformational changes, indicative for their activation, but BCL2 and BCLX retain significant activity in the course of M-arrest despite their extensive ...
However, characterization of the post-transcriptional regulators of MCL1 mRNA is limited. Polypyrimidine tract binding protein 1 (PTBP1) is a known regulator of post-transcriptional gene expression that can control mRNA splicing, translation, stability and localization. Here we demonstrate that PTBP1 ...
CCMCL1 Mantle Cell Lymphoma Cell Line CCMCL1 human mantle cell lymphoma cell line is well characterized at the molecular level and can support research and drug development efforts targeting MCL.; find Sigma-Aldrich-SCC132M MSDS, related peer-reviewed pa
牛诱导骨-髓白血-病细胞分化蛋白Mcl-1(MCL1)ELISA检测试剂盒检测原理:试剂盒采用双抗体一步夹心法酶联免疫吸附试验(ELISA)。往预先包被样本抗体的包被微孔中,依次加入标本、标准品、HRP标记的检测抗体,经过温育并 洗涤。用底物TMB显色,TMB在过氧化物酶的催化下转化成蓝色,并在酸的作用下转化成最终的黄色。颜色的...
MCL1 gene silencing promotes senescence and apoptosis of glioma cells via inhibition of the PI3K/Akt signaling pathway. DM Wu,XW Hong,X Wen,... - IUBMB Life 被引量: 0发表: 2019年 High immunohistochemical expression of p-AKT predicts inferior survival in patients with diffuse large B-cell ...
总的来说,临床前数据支持这样的假设:用BRD-810短期抑制 MCL1 可以诱导肿瘤细胞凋亡,同时保持可接受的安全性。因此,BRD-810将进行人体临床试验。 1. 背景介绍 对程序性细胞死亡的抵抗(细胞凋亡)是癌症的一个标志。每个正常细胞都有能力感知外...
首页/癌基因/ MCL1 该基因编码一种抗凋亡蛋白,属于bcl-2家族。选择性剪接导致多个转录变体。最长的基因产物(亚型1)通过抑制细胞凋亡来增强细胞存活,而交替剪接的较短的基因产物(亚型2和亚型3)则促进细胞凋亡并诱导死亡。[由RefSeq提供,2010年10月] This gene encodes an anti-apoptotic protein, which is a membe...
特别提示:包括Mcl1高效抑制剂(Pyridoclax)在内,本公司的所有产品仅可用于科研实验,严禁用于临床医疗及其他非科研用途! 产品名称:Mcl1高效抑制剂(Pyridoclax) 英文名称:Pyridoclax 产品货号:M01512 产品规格:1mL(10mM)|2mg|5mg|10mg|50mg|100mg Pyridoclax(MR-29072)是Mcl1高效抑制剂,Kd值为25nM。
Of note, other cell death pathways such as autophagy might have contributed to a ,15% decrease of prolifera- tion in Bax2/2/Bak2/2 MEFs caused by the combination, since MCL1-elimination triggers autophagic cell death when Bax is defected39,40. Basal expression of MCL1 correlates with mea...