ABT-737 is a small-molecule antagonist of BCL-2 currently under evaluation in clinical trials in the oral form of ABT-263. We anticipate that acquired resi... D.,Yecies,N.,... - 《Blood》 被引量: 427发表: 2010年 Hypoxic human cancer cells are sensitized to BH-3 mimetic–induced apop...
Acquired resistance to ABT-737 in lymphoma cells that up-regulate MCL-1 and BFL-1 Decreasing MCL-1 levels with flavopiridol, PHA 767491, or shRNA restored sensitivity to ABT-737 resistant cells. MCL-1 was up-regulated not by protein ... D.,Yecies,N.,... - 《Blood》 被引量: 427发表...
However, because ABT does not cross the blood–brain barrier, in animals treated with the deoxyglucose and ABT combination, the only cells exposed to both agents would be highly glycolytic cancer cells outside the brain. Indeed, in our experiments using cancer-bearing mice, the deoxyglucose-ABT...
Although Mcl-1 has been established as a survival and maintenance protein during in vitro incubations of primary CLL cells, in this issue of Blood , Pepper and colleagues further demonstrate the association of Mcl-1 with other prognostic factors and the role of this antiapoptotic protein in disea...
levels in 11 primary LUAD patient samples and matched healthy lung tissue. Notably, MCL-1 expression intensity was significantly higher in LUAD tissue than in healthy adjacent tissue (Fig.3g, h). These results are consistent with previous reports on MCL-1 protein abundance in lung cancer14,19...
Mcl-1 is a tightly regulated member of the Bcl-2 family that plays an important role in regulating the balance between life and death in a variety of cell types. Levels of Mcl-1 fluctuate dramatically in response to activated signalling pathways within the cell. Over-activation of survival si...
Levels of MCL-1, BCL-XL, BCL-2, BIM, PUMA, NOXA and p53 in breast cancer cell lines, immortalized breast epithelial cell lines and breast carcinoma. (a) Western blot using breast cell lines. Lysates from MCF10A cell lines were loaded in the first lane of each gel as a control for ...
ABBV-467 was also studied in a clinical trial in 8 patients with multiple myeloma, a blood cancer. In 1 patient, ABBV-467 treatment prevented the cancer from getting any worse for 8 months. However, in 4 out of 8 patients ABBV-467 increased the levels of troponin, a protein associated ...
Applications Reported: This LVUBKM antibody has been reported for use in flow cytometric analysis.Applications Tested: This LVUBKM antibody has been pre-diluted and tested by flow cytometric analysis of stimulated normal human peripheral blood cells. This may be used at 5 µL (0.25 µg) ...
In recent years, many studies have shown that MCL-1 is essential for the survival and development of cancer cells. High levels of MCL-1 have been reported in hematological malignancies and a wide range of solid tumors [37, 38]. Overexpression of MCL-1 in cancer cells disrupts the balance ...