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Consequently, MCL-1 inhibitors have great potential as single-agent therapies in primed, strongly MCL-1-dependent cancers (left panel). In tumors with either moderate priming status (e.g., solid tumors) or primed, but MCL-1 co-dependent status, combination therapies are of maximal benefit (...
MCL-1 differs in some key characteristics. MCL-1 is larger than other pro-survival BCL-2 family members. This is due to the presence of a N-terminal sequence rich in proline (P), glutamic acid (E), serine (S) and threonine (T) residues (PEST). The PEST sequence regulates MCL-1 t...
MCL-1 differs in some key characteristics. MCL-1 is larger than other pro-survival BCL-2 family members. This is due to the presence of a N-terminal sequence rich in proline (P), glutamic acid (E), serine (S) and threonine (T) residues (PEST). The PEST sequence regulates MCL-1 t...
lane 1, and an immunoprecipitation with a non-specific antibody (Ig) was run in lane 2. The positions of molecular weight markers (specified in kiloDaltons) are indicated on the left. (b) HCC-1806 breast cancer cells were incubated with increasing concentrations of A-1210477 (0.1, 0.5, 1...