The NSCLC cells (5 × 105) were suspended in 200 µL of diluted Matrigel and injected into the left flank of 4-weeks old nude mice. After the size of subcutaneous tumor reached 200 mm3, treatment was in
NSCLC cells were then suspended and counted at the concentration of 8000 cells/mL with the Eagle’s basal medium containing 10% FBS, 0.3% agar, and various doses of deguelin or gefitinib, followed by overlaid into the six-well plate containing a 0.6% agar base. The cultures were ...
Conclusion We show that cytarabine resistance potentially can be avoided or at least delayed through co-treatment with bortezomib, and that down-regulation of dCK and up-regulation of SPIB and NF-κB are the main molecular events driving cytarabine resistance development.Peer...
Epidermal growth factor receptor (EGFR) activating mutations play crucial roles in the tumorigenesis of human non-small cell lung cancer (NSCLC). The mechanism regarding how EGFR signaling regulates myeloid cell leukemia sequence 1 (Mcl-1) protein stabil
Epidermal growth factor receptor (EGFR) activating mutations play crucial roles in the tumorigenesis of human non-small cell lung cancer (NSCLC). The mechanism regarding how EGFR signaling regulates myeloid cell leukemia sequence 1 (Mcl-1) protein stabil