Total RNA of cells was extracted with Trizol kit (TaKaRa, Shiga, Japan). A total of 1ug RNA was reverse-transcribed to synthesis complementary DNA (cDNA) using PrimeScript RT reagent Kit (TaKaRa). The cDNAs were quantified by quantitative PCR (qPCR) with SYBR Green real time quantitative PCR...
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这些研究结果表明BTKi在R/R MCL中总体疗效可观,且泽布替尼具有显著的疗效优势。 本次大会上,MAIC研究比较了泽布替尼和奥布替尼在R/R MCL中的应用10,结果显示,基于CT/PET-CT评估疗效,两组患者的ORR相当(85.5% vs 82.1%;OR,1.28 [95...
Single-cell suspensions from the spleen or BM were cultured with A-1210477 (catalog number CT-A121, ChemieTek, Cell Death and Disease Acknowledgements. We thank the support facilities of our institute, particularly those responsible for animal husbandry and flow cytometry. We are grateful to ...
Ding Q, He X, Hsu JM, Xia W, Chen CT, Li LY, et al. Degradation of Mcl-1 by beta-TrCP mediates glycogen synthase kinase 3-induced tumor suppression and chemosensitization. Mol Cell Biol. 2007;27(11):4006–17. Article CAS PubMed Google Scholar Tong J, Wang P, Tan S, Chen D,...
Era 1~3,患者经历2L治疗的客观缓解率(ORR)逐渐上升分别为56%、80%和88%。完全缓解率也显著提高,分别为31%,54%和53%。 EFS和OS在不同时代均有显著改善,显示出治疗效果的提升。Era 1~3的估计2年EFS率分别为21%、40%和51% (...
Era 1~3,患者经历2L治疗的客观缓解率(ORR)逐渐上升分别为56%、80%和88%。完全缓解率也显著提高,分别为31%,54%和53%。 EFS和OS在不同时代均有显著改善,显示出治疗效果的提升。Era 1~3的估计2年EFS率分别为21%、40%和51% (p<0.001),估计5年OS率分别为31%、37%和67% (p<0.001)。
WGCNA_results.zip YRI_mt.gtf YRI_mtDNA.fasta correlated expression between mtDNA and nDNA-encoded genes in CEU.xlsx correlated expression between mtDNA and nDNA-encoded genes in YRI.xlsx modules_MCL.txt modules_power_5.txt modules_power_6_default.txt ...
如果可行,分子研究可包括IGHV基因的体细胞突变和/或体细胞突变的靶向DNA测序,TP53、NOTCH1/2、SMARCA4、NSD2和CCND1基因突变对预后有意义。必须对受累组织活检进行详细的组织病理学评估,以区分组织学侵袭性MCL(母细胞样/多形性)与经典组织学MCL。影像学包括对比增强PET-CT或CT进行评估。
2011/0245477; Yu et al., “Synthesis of Macrocyclic Natural Products by Catalyst-Controlled Stereoselective Ring-Closing Metathesis,” Nature 2011, 479, 88; and Peryshkov et al., “Z-Selective Olefin Metathesis Reactions Promoted by Tungsten Oxo Alkylidene Complexes,” J. Am. Chem. Soc. 2011,...