MCF-7 Molecular Profile MCF-7 breast cancer cells are estrogen E2-sensitive cells expressing high levels ofERαtranscripts and very low levels ofERβ.MCF7 cells increase expression of estrogen receptor (ER) in the absence of estrogens. Response to E2 of MCF7 cells was demonstrated to be depen...
Thus, MCF7 as the luminal A model, MB453 as the HER2 model and MB231 as the triple-negative model were used. No effect on cell growth and viability was detected in MB453 and MB231 cells. In MCF7 cells, hypocholesterolemia (1) reduced cell growth, and Ki67 expression; (2) increased...
HnRNPA2B1在乳腺癌细胞MCF7中的作用与机研究.docx,摘要上述研究结果表明,敲除hnRNPA2fBl会抑制乳腺癌细胞的增殖,促进其迁 摘要 上述研究结果表明,敲除hnRNPA2fBl会抑制乳腺癌细胞的增殖,促进其迁 移和侵袭,抑制其凋亡和自噬,而且hnRNPA2/B1与STAT3、NPM有相互作用。
HOXB8 and HOXB9 expression profiles in cell lines extensively used in the literature addressing the putative role of HOXB genes in breast cancer (MCF7, BT474, SKBR3, MDA231 and MDA468) and representative of the clinical breast cancer molecular subtypes (Luminal A, Luminal B, HER2+ and Tripl...
High expression levels of PKCε have also been shown to correlate with high tumor grade, HER2 expression, ER negativity, and poor survival in patients with breast cancer [83]. In vitro, PKCε has been shown to promote cell survival by inhibiting apoptosis of MCF7 cells and to promote EMT ...
represents the HER2 subtype (5%), the database generally coincides with the reported population prevalence [31]. It is important to recognize that gene expression in tumor samples, such as those described in Fig.7, does not imply that GR expression is restricted to tumor cells; the GR could...
The effect of epinephrine on the expression of DDC and the GiGi- protein was analyzed on the protein level via Western blot. A viability assay was performed to test the metabolic cell viability. The overexpression of DDC in the primary tumor was associated with longer OS (p = 0.03). ...
(B) of P5B ATPases ATP13A2-5 in MCF7 versus MCF10A cells. Expression of ATP13A2 (C), ATP13A3 (D) and ATP13A4 (E) was evaluated at the mRNA level via qPCR. mRNA expression was normalized to β-actin. Data in the bar graphs are presented as the mean of minimal three ...
mRNA expression z-Scores (RNA-seq V2 RSEM) for NR3C1 and for the eight mem- bers of the IAP gene family were selected. Because the classification of tumor samples into the luminal A, lu- minal B, HER2+, and triple negative breast cancer (TNBC) categories was not available, IHC data ...
Furthermore, these results postulated an attractive concept for developing a less-toxic differentiation-based therapeutic approach in treating HR + /HER2− breast cancer cells. 3.3 The expression level of PRLR is positively correlated with ESR1 expression in breast cancer patients It has been ...