miR-33b-5p胃癌增殖迁移侵袭凋亡目的:探讨lncRNA MCF2L-AS1对胃癌细胞恶性生物学行为的影响及分子机制.方法:选取45例胃癌患者的癌组织及癌旁正常组织,或培养胃黏膜上皮细胞GES-1,胃癌细胞HGC-27,采用RT-qPCR检测MCF2L-AS1和miR-33b-5p的表达水平.采用双荧光素酶报告实验检测MCF2L-AS1和miR-33b-5p的靶向关系....
colorectal cancerlncRNA MCF2L‐AS1miR‐874‐3pLong non‐coding RNAs (lncRNAs) have drawn growing attention because of the role which they play in various diseases, including colorectal cancer (CRC). However, the potential functions of lncRNA MCF2L antisense RNA 1 (MCF2L‐AS1) in tumors ...
We found high lncRNA MCF2L-AS1 expression in human bone marrow mesenchymal stem cells, and used bioinformatics analysis to analyze its function. MCF2L-AS1 knockdown induced inhibition of osteoblast differentiation. Silencing of MCF2L-AS1 increased the expression of miR-33a and subsequently inhibited ...