MCF10A细胞在RLO处理后，p53、Caspase-3、DMP1和p21的表达水平显著提高，而HER2的表达水平降低[6]。这些变化表明MCF10A细胞在受到特定化学物质刺激时，其信号通路和功能会发生调整，从而影响细胞的增殖和凋亡。在与乳腺癌细胞共培养后，MCF10A细胞表现出多种癌症相关途径的显著失调，包括代谢途径、细胞粘附、生长因子信...
Lee MY, Marina M, King JL, et al (2014). Differential expression of centrosome regulators in Her2+ breast cancer cells versus non-tumorigenic MCF10A cells. Cell Div, 9, 3.Lee MY, Marina M, King JL, Saavedra HI. Differential expression of centrosome regulators in Her2+ breast cancer cells...
Sigma-Aldrich CLLS1069 MCF10A CELLS APC (-/-) Preis und Verfügbarkeit anzeigen MCF7 Cell Line human Preis und Verfügbarkeit anzeigen Sigma-Aldrich CLLS1045 MCF10A CELLS HER2 (-/-) Preis und Verfügbarkeit anzeigen Sigma-Aldrich CLLS1042 MCF10A CELLS CDH1 (-/-) Preis und Verfügbarkei...
R. et al. Modeling ductal carcinoma in situ: A HER2–Notch3 collaboration enables luminal filling. Oncogene 31(7), 907–917. https://doi.org/10.1038/onc.2011.279 (2012). Article PubMed CAS Google Scholar Geissler, K. & Zach, O. Pathways involved in Drosophila and human cancer ...
Previous studies indicated that RECK expression is a com- mon target of repression by various oncogenic signals (such as HER2, Ras, Src, PI3K, and hypoxia) via multiple mechanisms (such as tran- scriptional repression, DNA methylation, and microRNAs)6,19,30–34. The results of our present...
HOXB8 and HOXB9 expression profiles in cell lines extensively used in the literature addressing the putative role of HOXB genes in breast cancer (MCF7, BT474, SKBR3, MDA231 and MDA468) and representative of the clinical breast cancer molecular subtypes (Luminal A, Luminal B, HER2+ and Tripl...
SK-BR-3细胞系;细胞传代方法:消化3-5分钟,1:2,3天内可长满;细胞形态特性:上皮样;细胞生长特性:贴壁生长;细胞背景资料:这株细胞源自胸水。没有病毒颗粒。亚显微结构特征包括微丝和桥粒,肝糖原颗粒,大溶酶体,成束的细胞质纤丝。SK-BR-3细胞株过表达HER2/c-erb-2基因产物。
MCF10A细胞在RLO处理后,p53、Caspase-3、DMP1和p21的表达水平显著提高,而HER2的表达水平降低[6]。这些变化表明MCF10A细胞在受到特定化学物质刺激时,其信号通路和功能会发生调整,从而影响细胞的增殖和凋亡。 在与乳腺癌细胞共培养后,MCF10A细胞表现出多种癌症相关途径的显著失调,包括代谢途径、细胞粘附、生长因子信号...
Two clones differentially overexpressing Bag-1L were grown in two-dimensional (2D) and three-dimensional (3D) cultures and compared with an established model of HER2-driven transformation. In 2D cultures, Bag-1L overexpression reduced proliferation but did not affect growth factor responsiveness or ...
For xenograft studies, 2 X 106 cells in 80% growth factor reduced Matrigel and 20% PBS were implanted subcutaneously.Results: Stable knock down (KD) of HOXA5 using shRNAs in the V777L DKI cell line (HER2 V777L and PIK3CA E545K) resulted in a more spindle like, elongated morphology. ...