No.: HY-76847CAS No.: 474-25-9分式: CHO分量: 392.57作靶点: FXR; Endogenous Metabolite; Autophagy作通路: Metabolic Enzyme/Protease; Autophagy储存式: 4C, protect from light* In solvent : -80C, 6 months; -20C, 1 month (protect from light)溶解性数据体外实验 DMSO : 50 mg/mL (127.37 ...
英文名称: CDCA-d5 总访问: 33 国产/进口: 进口 半年访问: 3 产地/品牌: MedChemExpress(MCE) 产品类别: 生化试剂 规格: 电询 最后更新: 2024-11-4 货号: HY-76847S3 CAS 号: 52840-12-7 参考报价: 电询 立即询价 电话咨询 [发表评论] [本类其他产品] [本类其他供应商] [收藏] 分享:微信...
Farnesoid_X_receptor抑制剂_激动剂_MCE FXR Farnesoid X receptor encoded by the NR1H4 gene in humans. FXR is expressed at high levels in the liver and intestine. Chenodeoxycholic acid and other bile acids are natural ligands for FXR. When activated, FXR translocates to the cell nucleus, forms ...
(HY-76847)withanIC50valueof3.0μM.F44-A13isalow-toxicity,highlyselectiveFXRantagonist[1].F44-A13(F44-A13:3,10,30μM;CDCA:100μM;24hours)canimprovecholesterolmetabolismandreducecholesterolactivitybyinducingtheexpressionofCYP7A1.F44-A13candecreasetheexpressionlevelofShpandBsep,andincreasetheexpressionlevel...
No.: HY-76847BMS-986318 is a potent nonbile acid FXR agonistwith EC s of 53 and 350 nM in the FXR Gal4 and50SRC-1 recruitment assays, respectively. BMS-986318has a suitable ADME profile, and demonstratesefficacy in the mouse bile duct ligation 10、model ofliver cholestasis and fibrosis...
货号 HY-76847应用领域 医疗卫生,化工,生物产业,制药 Chenodeoxycholic Acid 是一种疏水初级胆汁酸,能够活化核受体 FXR,该受体与胆固醇代谢有关。 详细介绍 产品活性:Chenodeoxycholic Acid 是一种疏水初级胆汁酸,能够活化核受体 FXR,该受体与胆固醇代谢有关。 品牌介绍: MCE (MedChemExpress) 拥有数百种*仅有化合...