The planar structure of new compound 1 was determined by extensive analysis of the NMR and HRESIMS spectra. The relative and absolute configurations of 1 were resolved by the coupling constant (J), calculation of ECD and NMR spectra, and the DP4+ probability analysis of the 1H and 13C NMR...
Three new cyclopiane diterpenes (1-3) and one rare spirocyclolide (5) were isolated from the deep-sea-derived fungus Penicillium commune MCCC 3A00940, along with 11 known compounds. The planar structures of the new compounds were determined by extensive analysis of their NMR and HRESIMS spect...
Compound 4 was established the molecular formula C15H24O2 on the basis of its HRESIMS. The 1H and 13C NMR spectra were very similar to those of 3 except that a ketone group (δC 220.6) rather than a hydroxy unit was located at C-3. The assumption was corroborated by the HMBC relation...
The planar structure of 1 was established mainly on the basis of extensive analysis of its 1D, 2D NMR, and HRESIMS spectra. The absolute configuration of 1 was determined by comparison of the calculated and experimental electronic circular dichroism spectra. Compounds 5, 6, and 7 exhibited ...
Two more stable derivatives (2 and 3) were obtained by methylation. Bioassay verified the new compounds 2 and 3 as potent tau-aggregation inhibitors, and 2 could protect HT22 cells from OA-induced damage via suppressing tau aggregates. Herein, we reported the isolation, structural identification,...
Two new compounds, compounds 1 and 2, were obtained from the culture of a marine-derived fungus Talaromyces sp. MCCC 3A01752, together with 13 known compounds (3-15). Their structures were elucidated based on detailed analysis of NMR, HRESIMS, ECD spectra and OR value. Compound 1 ...
The structures of the new steroids were established mainly on the basis of extensive analysis of 1D and 2D NMR as well as HRESIMS data. Moreover, the absolute configurations of 1 were confirmed unambiguously by the single-crystal X-ray crystallography. Compounds 2 and 4–7 showed moderate ...
marine drugs Article Chemical Constituents of the Deep-Sea-Derived Penicillium citreonigrum MCCC 3A00169 and Their Antiproliferative Effects Zheng-Biao Zou 1,2,†, Gang Zhang 3,†, Yu-Qi Zhou 4,†, Chun-Lan Xie 2, Ming-Min Xie 2, Lin Xu 2, You-Jia Hao 2, Lian-Zhong Luo 3,...