Identification of novel genetic risk factors is imperative for a better understanding of B lymphomagenesis and for the development of novel therapeutic strategies. TRAF3, a critical regulator of B cell survival, was recently recognized as a tumor suppres
The T allele and TT genotype of rs2227947 were significantly more common in schizophrenia group compared to control group (allele, 71.6% versus 63.4%, OR 0.69, 95% CI 0.53–0.89; genotype, 51.5% versus 42.1%). Moreover, we further assessed the allele frequencies of the four markers in ...
Base stacking in [d(5mCCTTTACC)]2. The same color-coding is used as in Figure 9. (a) The adenosine of strand b is stacked to C8{a} and T3 is flipped out into the wide groove. (b) Stacking of 5mC1·C7+ onto C8·C2+. The groove between residues C7 and C8 is broader than ...
Eukaryotic genes that encode polypeptides are composed of coding sequences calledexons(ex-on signifies that they areexpressed) and intervening sequences calledintrons(int-ron denotes theirintervening role). Transcribed RNA sequences corresponding to introns do not encode regions of the functional polypepti...
What are some functions of noncoding DNA? In the chromatin of eukaryotic cells, which regions of the chromosome would you expect to be more compact: the regions that contain genes being actively copied into RNA or those that contain inactive genes?