Identification of novel genetic risk factors is imperative for a better understanding of B lymphomagenesis and for the development of novel therapeutic strategies. TRAF3, a critical regulator of B cell survival, was recently recognized as a tumor suppres
Base stacking in [d(5mCCTTTACC)]2. The same color-coding is used as in Figure 9. (a) The adenosine of strand b is stacked to C8{a} and T3 is flipped out into the wide groove. (b) Stacking of 5mC1·C7+ onto C8·C2+. The groove between residues C7 and C8 is broader than ...
Eukaryotic genes that encode polypeptides are composed of coding sequences calledexons(ex-on signifies that they areexpressed) and intervening sequences calledintrons(int-ron denotes theirintervening role). Transcribed RNA sequences corresponding to introns do not encode regions of the functional polypepti...
Prokaryotic and eukaryotic genomes both containnoncoding DNA, the function of which is not well understood. Some noncoding DNA appears to participate in the formation of small noncoding RNA molecules that influence gene expression; some appears to play a role in maintaining chromosomal structure and ...