Microcrystalline cellulose 102 (Avicel PH102) was used as model powder and soluble grades of Kollidon (PVP) as a binder to investigate behavior of granules formed during and after granulation. Each batch was individually granulated with 15%w/w solution of three different soluble grades of Kollidon...
PH-102 Particle Size % / >250um(60 mesh) ≤1.0 >250um(60 mesh ≤8.0 / >75um(200 mesh) ≤30.0 >75um(200 mesh) ≤45.0 Loss on drying % ≤5.0 ≤5.0 ≤5.0 Bulk Density, g/ml / 0.26-0.31 0.28-0.33 PH 5.0-7.5 5.0-7.0
pH 5.0-7.0 Ether-soluble Matter(%) NMT0.05 Water-soluble Matter(%) NMT0.24 Heavy Metals NMT10PPM Residue on Ignition(Sulphated ash)(%) NMT0.05 Loss on Drying(%) NMT7.0 Bulk Density(g/cm3) 0.28-0.33 Conductivity(uS) NMT 75 Particle Size: Retained 60 mesh(250 microns)(%) Retai...
PH-102 Particle Size % / >250um(60 mesh) ≤1.0 >250um(60 mesh ≤8.0 / >75um(200 mesh) ≤30.0 >75um(200 mesh) ≤45.0 Loss on drying % ≤5.0 ≤5.0 ≤5.0 Bulk Density, g/ml / 0.26-0.31 0.28-0.33 PH 5.0-7.5 5.0-7.0
•AbsorbsmorewaterfromthegranulethanAvicelPH-200 •Enablescompressionwithoutfurtherdrying LargerparticlesizeMH-200LM(180µmnominal)isidealforblendingwith themoistgranulates 1010 StepsinMoistureActivatedDryGranulation Step1–Determinerawmaterialmoistureinputandumacceptable ...
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This paper focuses on the characterization of the tabletting process and analysis one of the most common pharmaceutical excipients MCC Avicel PH102 by Heckel, Kawakita, Cooper-Eaton and Adams compaction equations. Experimental material was determined by measuring its parameters as particle size ...
Not only did these cells express increased levels of the proliferation markers Ki67 and pHH3, but the apoptosis marker also cleaved caspase 3 (CC3). This finding was also consistent in adult transgenic mice, which used a Cre-inducible system to drive the expression of ST in K5+ cells upon...