The Pd-l1 Knockout colon adenocarcinoma MC38 cell line is invalidated for murine Pd-l1 and can be used for target validation and mechanistic studies.
*使用本品系发表的文献需注明: MC38-hPD-L1(2) cell line (Cat. NO. NM-S13-TM86) was purchased from Shanghai Model Organisms Center, Inc.. 验证数据 Figure 1. Expression of human PD-L1 on MC38-hPD-L1 cells was confirmed by flow cytometry. MC38-hPD-L1 cells and wild type MC38 cel...
与内源免疫不同，合成免疫可以使免疫原性差的癌症产生抗肿瘤免疫。不过合成免疫也常导致PD-L1表达的增加，反过来抑制合成免疫的效果[13]。另一方面，内源免疫能够激活多种特异性免疫反应，可以形成持久的抗肿瘤反应，这是合成免疫不一定能够做到的。合理猜测，内源免疫与合成免疫可能存在相辅相成的作用。不过这两者能否...
该文献是2022年3月发表在Clinical Cancer Research(IF=12.531)上,原文标题《A Paradigm of Cancer Immunotherapy Based on 2-[18F]FDG and Anti–PD-L1 mAb Combination to Enhance the Antitumor Effect》,该研究主要探索2-[18F]FDG可以诱导PD-L1表达变化并为肿瘤免疫治疗创造有利于免疫的微环境。 研究背景: 免疫...
Here we continue characterization of a C57BL/6 transgenic mouse model expressing both the human PD-1 and PD-L1 combined with a modified murine MC38 colon tumor cell line expressing human PD-L1. Both PD-1 and PD-L1 expression of the transgenic mice were verified in ex vivo stimulated sple...
Characterization of the Anti-PD-1 Antibody REGN2810 and Its Antitumor Activity in Human PD-1 Knock-In Mice. The Programmed Death-1 (PD-1) receptor delivers inhibitory checkpoint signals to activated T cells upon binding to its ligands PD-L1 and PD-L2 expressed on... Elena,Burova,Aynur,.....
Figure 4. Antitumor activity of Tencentriq and another anti-PDL1 antibody (n=8). 相关品系 HEK293-CMV-cynoPD-L1-Tg 细胞系名称:HEK293-CMV-cynoPD-L1-Tg 目录号:NMC-230128 HEK293-CMV-hPD-L1-Tg 细胞系名称:HEK293-CMV-hPD-L1-Tg 目录号:NMC-230126 ...
The genO‑MC38-hPD-L1-hCD47-LZ clonal cell line expresses high levels of human PD-L1 and human CD47. genO-hCT26-hPD‑L1 The humanized hPD-L1 syngeneic clonal colon carcinoma CT26 cell line expresses high levels of human PD-L1 and forms solid tumorsin vivo....
In contrast, anti-PD-L1 and anti-PD-1 treatments produced clear anti-tumor activities with 40 and 50% putative responders and 35 and 37% increase in time to progression, respectively, as compared to controls. Tumor volumes in anti-PD-L1 and anti-PD-1 treated mice were also smaller than ...
Figure 4. Antitumor activity of Tencentriq and another anti-PDL1 antibody (n=8). 相关品系 HEK293-CMV-cynoPD-L1-Tg 细胞系名称:HEK293-CMV-cynoPD-L1-Tg 目录号:NMC-230128 HEK293-CMV-hPD-L1-Tg 细胞系名称:HEK293-CMV-hPD-L1-Tg 目录号:NMC-230126 ...