which in turn activate the classical pathway. MBL deficiency is inherited in an autosomal co-dominant manner, with heterozygotes having about 10% of the normal functional level of MBL and homozygotes having less than 1% functional levels of MBL. Mannose-binding lectin / MBL deficiency has been ...
Literature data are uncertain regarding the role of MBL deficit as a predictor factor for poor outcome in CF. Objectives The assessment of serum MBL levels among CF children with severe lung disease and evaluation of MBL deficiency as risk factor. Methods Group 1 included 15 children with ...
Deficiency of mannose-binding lectin (MBL), one of the most important proteins of innate immunity, alters susceptibility to infection. Using a hemolytic assay, we investigated functional MBL serum levels in a cohort of pneumonia patients from a legionellosis outbreak in the Netherlands in 1999 (n...
要 月经过多(heavy menstrual bleeding,HMB)是妇科门诊女性患者就诊最常见的原因之一,对女性生活质量、工作效率、医疗成本产生重大影响。女性对自身月经失血量(menstrual blood loss,MBL)的认知是诊断和治疗HMB的关键决定因素。自从50多年前报道的碱性血红素法以来,许多新...
18. Christiansen, O,B., Kilpatrick, D.C., Souter, V., Vanning, K., Thid, S., Jensenius,J.C. (1999) Mannan-binding lectin deficiency is associated with unexplained recurrent miscarriage. Scand. J. Immunol., 49, 193-196 19. Garred, P, Harboe, M, Oettinger, T, Koch, C, and Sve...
关键词 甘露聚糖结合凝集素 GGC54GAC突变体 定点突变ConstructionofGGC54GACmutantofmannan2bindinglectinCHENZheng2Liang,LUXiao,ZHANGLi2Yunetal.DepartmentofImmunology,FirstMilitaryMedicalUniversity,Guangzhou510515Abstract Objective:Toexplorethemechanismsofmannan2bindinglectin(MBL)deficiency,theGGC54GACMBLmutantwascon2...
Grondahl-Yli-Hannuksela K, Viander M, Mertsola J, He Q (2013) Increased risk of pertussis in adult patients with mannose-binding lectin deficiency. APMIS 23030784 Pradhan V, Mahant G, Rajadhyaksha A, Surve P, Rajendran V, Patwardhan M, Nadkarni A, Dighe S, Ghosh K. (2013) A study...
Our study further supports the notion that neonates with MBL deficiency and low MBL serum levels at birth may be at higher risk of developing severe respiratory complications. 展开 关键词: Microbiology and Immunology Allergy and Clinical Immunology ...
MBL deficiency may be associated with increased susceptibility to infectious disease and autoimmune disorders.关键词: school-entry vaccination laws DOI: 10.1542/peds.2007-2022FFFF 年份: 2008 收藏 引用 批量引用 报错 分享 全部来源 免费下载 求助全文 Semantic Scholar dx.doi.org ResearchGate ResearchGate ...
MBL途径补体激活与糖尿病肾病进展的相关性研究