Results: Compared to healthy controls, leukocyte adhesion was significantly increased in DSS colitis (adherent leukocytes 23.7 ± 8.7 vs. 0.6 ± 0.4; rolling leukocytes 67.1 ± 30.2 vs. 24.9 ± 10.4/0.01 mm 2 /3
Western blots showed a quantitatively reduced expression of occludin, claudin-1, -2 and -4 for DSS + placebo. VSL#3 prevented this decrease in expression. Conclusion: The probiotic mixture VSL#3 preserves the epithelial barrier by preventing the redistribution and the decrease in expression of ...
Mouse colon carcinoma cells CT26 were implanted into different organ sites in syngeneic BALB/c mice. DOX at 10 mg/kg was given i.v. on days 3 and 10, 7 and 14, or 14 and 21, and 5-FU at 20 mg/kg in 6 subsequent doses starting day 3, 7, or 10. In the liver, spleen, ...