Since Schwann cells (SCs) support axonal growth at development as well as after peripheral nerve injury (PNI), developing SCs might be able to promote axon regeneration after PNI. The purpose of the current study was to elucidate the capability of develo
26,33,41. While Mfn1 mainly resides on mitochondria, Mfn2 is sorted to both the mitochondrial OMM and ER, where Mfn2 has been reported to regulate ER-Mito contacts in non-neuronal cells19,20,21,22. We sought to examine whether Mul1 deficiency alters ER-Mito contacts...
there is also growing evidence that sex-hormone, particularly estrogen, may have neuroprotective effects. Pretreatment with estrogen protected against glutamate excitotoxicity in neuronsin vitro, and the effect could be blocked with tamoxifen, a specific antagonist of the estrogen ...
In mice models of amyotrophic lateral sclerosis, it has been demonstrated that NMJ disruption precedes subsequent motor neuron death [59], demonstrating a critical primary role for NMJ maintenance in the etiology of this neurodegenerative disease. Together, these findings reveal that cells at the ...
Lamprianou S., Vacaresse N., Suzuki Y., Buxbaum J. D., Schlessinger J., et al. (2006) Receptor tyrosine phosphatase-gamma (RPTPγ) is a marker for pyramidal cells and sensory neurons in the nervous system and is not necessary for normal development.Mol. Cell Biol.in press. ...
an OPC-specific surface marker (Fig.1b). To examine the complexity of OPC morphology, cellular processes were traced and subsequently analysed using Sholl analysis, which quantifies the number of process intersections against the radial distance from the soma center25,26. While gmOPCs and wmOPCs...
These data showed that increase in the excitatory synapse marker PSD-95 induced by learning at PN17 is required for a second episodic learning to mature the functional competence of the long-term memory system. The PSD-95-dependent changes require >6 h in order to allow for sufficient biolo...
Ischemic stroke is a critical disease caused by cerebral artery occlusion in the central nervous system (CNS). Recent therapeutic advances, such as neuroendovascular intervention and thrombolytic therapy, have allowed recanalization of occluded brain art