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Naive mesenchymal stem cells (MSCs) from human bone marrow will be shown to specify lineage and commit to phenotypes with extreme sensitivity to tissue level elasticity. Soft matrices that mimic brain appear neurogenic, stiffer matrices that mimic muscle are myogenic, and comparatively rigid matrices ...
(B) Crosstalk between signal transduction pathways induced by matrix stiffness to modulate stem cell lineage specification. Left: blocking of BMP/Smad signaling by enhanced uptake of β1 integrin through caveolae/raft-dependent endocytosis on soft matrix drives mesenchymal stem cell (MSC) neurogenic dif...
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Matrix elasticity directs stem cell lineage specification Adhesion of stem cells - like most cells - is not just a membrane phenomenon. Most tissue cells need to adhere to a ``solid'' for viability, and over the l... D Discher - Aps March Meeting 被引量: 8355发表: 2010年 Limitation of...
A Heteroskedasticity-Consistent Covariance Matrix Estimator and a Direct Test for Heteroskedasticity Convergent and discriminant validation by the multitrait-multimethod matrix. Engler AJ, Sen S, Sweeney HL, Discher DE.. Matrix elasticity directs stem cell lineage specification. Cell 126: 677-689 ...
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