An important factor in transcript destabilization, SMAUG (SMG), was first identified as a protein that represses translation of nanos mRNA in the bulk cytoplasm of the early embryo by binding to 3′ untranslated region (UTR) elements known as SMG response elements (SREs) (Dahanukar et al., ...
perspective, dysregulation of the maternal mRNA clearance process may be related to various disorders of the reproductive system, such as follicle growth retardation, oocyte maturation defects, early embryo arrest, oocyte aging, and ultimately, infertility6,9,12,23,24. Thus, investigating the stability...
Zygote arrest 1 (Zar1) is an oocyte-specific maternal-effect gene that functions at the oocyte-to-embryo transition in many vertebrate species including ... G Michailidis,A Argiriou,M Avdi - 《Veterinary Research Communications》 被引量: 29发表: 2010年 Non-promoter hypermethylation of zygote ...
As the spatial organisation of the egg cell arises during oogenesis, such mutants are likely to affect the embryo via the maternal genome (maternal effect). In Drosophila, most maternal-effect mutants studied so far lead to early developmental arrest. A few others yield pattern defects apparently...
During the peri-implantation, the expression of collagen type I, III, VI disappear from the decidua upon embryo. Whereas, collagen type IV accumulates in the decidua, and also expressed highly in embryonic basement membranes [62]. During the establishment of pregnancy, placentation involves in ...
Wu X, Viveiros MM, Eppig JJ, Bai Y, Fitzpatrick SL, Matzuk MM: Zygote arrest 1 (Zar1) is a novel maternal-effect gene criti- cal for the oocyte-to-embryo transition. Nat Genet 2003, 33:187-191.Wu, X., Viveiros, M.M., Eppig, J.J., Bai, Y., Fitzpatrick, S.L. and Mat...
To assess the effect of PM2.5 in vitro, TM4 cells, a Sertoli-like cell line, was treated with different concentrations (0, 25, 50, 100 μg/mL) of PM2.5 for 24 h. The results displayed that Sperm motility, as well as the number of adult offspring, was decreased in the PM2.5 ...
To investigate the underlying relationship between AMA-induced changes in the DNA methylome and adverse pregnancy outcomes in AMA, we further obtained the DNA methylome of CVS from spontaneous abortion (SA) patients (27.55 ± 2.77; embryo gender: female,n = 5; male,n = 7) and...
The embryo sac contains the haploid maternal cell types necessary for double fertilization and subsequent seed development in plants. Large-scale identification of genes expressed in the embryo sac remains cumbersome because of its inherent microscopic a
Removal of maternal mRNA during embryo development Maternally derived messenger RNAs (mRNAs) are used for the early development of the embryo until transcription starts in the embryo, when maternal mRNAs are degraded. But how is this controlled? Chuan He and colleagues find that zebrafish maternal ...