These results suggest that MAML1 may be turned-over to maintain low protein levels in the absence of Notch. Upon Notch cleavage and translocation to the nucleus, MAML1 becomes more stable to help form the ternary complex for transcriptional activation of target genes. This research was supported...
基因名 MAML2 基因全名 Mastermind-like protein 2 蛋白功能 Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Potentiates activation by NOTCH3 and NOTCH4 more efficiently than MAML1 or MAML3. . Tissue Specificity Widely expressed...
化学名:MAML3 (Mastermind-like Protein 3, KIAA1816) (MaxLight 650)CAS番号. 英語名:MAML3 (Mastermind-like Protein 3, KIAA1816) (MaxLight 650)CBNumberCB04968434MW0MOL FileMol fileMAML3 (Mastermind-like Protein 3, KIAA1816) (MaxLight 650) 生産企業 ...
MAML1, ID (MAML1, KIAA0200, Mastermind-like protein 1) 供应商 MyBioSource 产品货号 MBS641464 产品报价 ￥询价/0.2mL ￥询价/5x0.2mL ￥询价/其它规格 产品说明书 点击查看 购买方式 MyBioSource中国区金牌代理,部分产品现货库存。银行转账、电汇、支票、现金,在线支付宝及网银支付,或直接与我们电话联系400...
Moreover, as determined by using coimmunoprecipitation assays, each MAML protein was found to be capable of forming a multiprotein complex with the intracellular domain of each Notch receptor (ICN1 to -4) and CSL in vivo. However, MAML3 bound less efficiently to the ankyrin repeat domain of...
基因全名Mastermind-like protein 3 蛋白功能Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. . Uniprot IDMAML3 :Q96JK9 产品应用细节 为了提供最优质的抗体,博士德对每一批抗体都用没有转染过的细胞系和体细胞组织检测,以保证博士德出...
To activate target genes, the Notch intracellular domain (NICD) forms a complex with CBF1 and Mastermind-like protein (MAM). The Notch activation complex binds to a response element containing the consensus sequence RTGRGAR (R= purine) on target gene promoters. The promoter of one well ...
MAML3 (Mastermind-like Protein 3, KIAA1816) (MaxLight 650) 中文名: 中文别名: CBNumber: CB04968434 分子式: 分子量: 0 MOL File: Mol file 化学性质安全信息用途供应商1 MAML3 (Mastermind-like Protein 3, KIAA1816) (MaxLight 650)化学性质 ...
Review on MAML2 (mastermind-like 2), with data on DNA, on the protein encoded, and where the gene is implicated.doi:10.4267/2042/37983G. StenmanJean-Loup Huret (Editor-in-Chief) ; INIST-CNRS (Publisher)Atlas of genetics and cytogenetics in oncology and haematology...
Inhibition of MAML-protein activity by a dominant negative form of MAML or by small hairpin RNAs targeting MAML2 in cHL cells resulted in downregulation of the NOTCH target genes HES7 and HEY1, which we identified as overexpressed in cHL cells, and in reduced proliferation. Furthermore, a ...