We recently cloned a mammalian homologue of the Mastermind gene of Drosophila melanogaster, MAML1 (Mastermind-like-1 molecule) and determined that it functions as a transcriptional coactivator for Notch receptors. In this report, we characterize two additional genes in this Mastermind-like gene family...
However, the mechanism of beta-catenin-mediated transcriptional activation remains poorly understood. In this study, we identified Mastermind-like 1 (Maml1), which is thought to be a specific coactivator for the Notch pathway, as a coactivator for beta-catenin. We found that Maml1 participates ...
产品名称 MAML2 (Mastermind Like Transcriptional Coactivator 2) Antibody 产品描述 Anti-MAML2 (Mastermind Like Transcriptional Coactivator 2) Antibody 文献引用格式 MAML2 (Mastermind Like Transcriptional Coactivator 2) Antibody (Boster Biological Technology, Wuhan, China. Catalog #M03679) 应用范围 IF, IHC...
该MAML2 (Mastermind Like Transcriptional Coactivator 2) (MAML2/1302), Biotin conjugate, 0.1mg/mL产品反应性待更新请参考产品说明书 保存建议 室温 其他 Biotium公司是一家在荧光技术领域独树一帜的生物技术公司,公司位于美国加利福尼亚的BAY AREA---中外知名首要的生物科技中心。该公司一直致力于开发和生产用于...
A Dynamic Role of Mastermind-Like 1: A Journey Through the Main (Path)ways Between Development and Cancerdoi:10.3389/fcell.2020.613557MAMLNotchHedgehogHipposignaling pathwaydevelopmentcoactivatorCancerMajor signaling pathways, such as Notch, Hedgehog (Hh), Wnt/?-catenin and Hippo, are targeted by a ...
Mastermind-like 1 (MAML1) was originally identified as a Notch coactivator, but has also been reported to function as a transcriptional coregulator of ... SJR Mariana,ML Hansson,MJ Lindberg,... - 《Nucleic Acids Research》 被引量: 59发表: 2009年 MAML1 Acts Cooperatively with EGR1 to Acti...
Transcriptional Mechanisms by the Coregulator MAML1 The Mastermind-like (MAML) proteins are transcriptional coactivators for Notch signaling, an evolutionarily conserved pathway that plays several key roles ... M. Saint Just Ribeiro, A. E. Wallberg - 《Curr Protein Pept Sci》...
基因全名Mastermind-like protein 3 蛋白功能Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. . Uniprot IDMAML3 :Q96JK9 产品应用细节 为了提供最优质的抗体,博士德对每一批抗体都用没有转染过的细胞系和体细胞组织检测,以保证博士德出...
Mucoepidermoid carcinoma is one of the most common malignant tumors in salivary glands and is usually associated with mastermind-like transcriptional coactivator 2 (MAML2) rearrangement. Primary nasopharyngeal mucoepidermoid carcinoma is extremely rare, and MAML2 status was reported in only ...
Here, we demonstrate that aberrant expression of an essential NOTCH coactivator of the Mastermind-like (MAML) family provides an alternative mechanism to activate NOTCH signaling in human lymphoma cells. We detected high-level MAML2 expression in several B cell-derived lymphoma types, including ...