Another single-cell analysis showed that although the density of mast cells in colorectal cancer was lower than in normal tissue, resting mast cells with high expression of chymase1 (CAM1) were activated to mast cells with high expression of TPSAB1, CPA3, and KIT [114]. These findings ...
massive expansion of mast cell in polyposis-prone mice, overexpression of IL-10 by T cells does not lead to an increase in polyp formation. This suggests a dual role for IL-10: while it promotes mast cell expansion, it also enhances T cell immunosurveillance and supports the recovery of reg...
Clustering analysis revealed eight-cell clusters, identified as smooth muscle cells, dendritic cells, mast cells, and T cells, respectively. Cluster 6 was identified as mast cells with the marker genes TPSAB1, CPA3, TPSB2, MS4A2,KIT, etc., which accounting for 2.7% of the total cell ...
negative effect of IL-3 onMcpt1mRNA and protein expression in the immortalized mast cell line PMC-306 but not in bone marrow-derived mast cells. Therefore, extracellular signal-regulated kinases ERK1/2 are identified as a mutual switch between IL-3-driven proliferation and TGF-β1-promoted muc...
(CPA3), histamine, and heparin proteoglycans [11,12]. These CTMCs are predominantly present in the skin and peritoneum and can be isolated and cultured from the peritoneal cavity as peritoneum-derived MCs (PMCs) [13]. On the other hand, mucosal MCs (MMCs) lack tryptase and instead contain...
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Concomitant with the increase in mast cell number in K5-R1/R2 mice, we observed an increase in the mRNA levels of Mcp4, Mcp6, and Cpa3 (Figure 1B). In young K5-R1/R2 mice, most of the mast cells were degranulated (Figure 1, C and D), followed by a decrease in degranulated ...
Notably, CPA3 is a characteristic feature of MCtc (MC type containing tryptase, chymase, and CPA3), which allows it to distinguish this type of MC from MCt [4,13,42]. Another vital substance stored in mast cell granules is histamine. It is an essential mediator, acting via four ...
Defective bone repair in mast cell-deficient Cpa3Cre/+ mice. PLoS ONE 2017, 12, e0174396. [CrossRef] [PubMed] 23. Ngkelo, A.; Richart, A.; Kirk, J.A.; Bonnin, P.; Vilar, J.; Lemitre, M.; Marck, P.; Branchereau, M.; Le Gall, S.; Renault, N.; et al. Mast cells ...
The present disclosure provides methods for the treatment of mast cell gastritis, mast cell esophagitis, mast cell colitis, mast cell enteritis, mast cell duodenitis, and/or mast cell gastroenteritis. In particular, the present disclosure provides methods for the treatment of mast cell gastritis, mas...