aSynovial membranes from OA and RA patients were digested into single-cell suspension. Synovial mast cells were gated as CD45+CD117+FcεRI+cells. Numbers indicated the percentages of mast cells in the gates.bStatistical analysis of mast cell percentage in synovial single-cell suspensions and CD...
The mast cell expansion in IL-4-treated wild-type and Il4raF709 mice occurred predominantly in the lamina propria, although a few mast cells were also observed in the villi and intestinal epithelium. Flow cytometry was used to quantify mast cells (CD45 þ lin À c-Kit þ IgE þ ...
Mast cell heterogeneity in the human uvea. His- tochem. Cell Biol. 112, 381-386.May CA. Mast cell heterogeneity in the human uvea. His- tochem Cell Biol. 1999;112:381-386.May CA (1999) Mast cell heterogeneity in the human uvea. Histo- chem Cell Biol 112:381-386...
All uveal mast cells were c-kit and CD45 positive and HLA-DR negative. No association existed between mast cells and actin-containing cells. Only a few mast cells were in close association with PGP 9.5-labeled nerve fibers. In the choroid, most mast cells were located in the inner central...
271 Mast cells express tryptase, leukocyte common antigen (CD45), CD43, CD68, MCG-35,275 3G5,276 and CD117, the c-kit encoded tyrosine kinase receptor protein.277,278 Microphthalmia transcription factor (MITF) has also been detected in mast cells.279 The role of genetics in mast cell ...
NT can stimulate lymphocyte proliferation [22], activate T cells [23], enhance IL-1 production from macrophages [24], and trigger mast cell activation [25]. Unlike NT, substance P (SP) was not elevated as also previously reported [26], [27];β-endorphin was also not elevated, even ...
CD8 T cells are classified as nave, effector, or memory cells on the basis of CD45RA, CD62L, and CCR7 expression. Sequential engagement of cell-surface CD6... G Chen,P Shankar,C Lange,... - 《Blood》 被引量: 430发表: 2001年 Natural Killer Cells Promote Early CD8 T Cell Responses...
Pulmonary fibrosis was induced with bleomycin in mast-cell-deficient WBB6F1-W/W-v (MCD) mice and their congenic controls (WBB6F1-(+)/(+)). Mast cell deficiency protected against bleomycin-induced pulmonary fibrosis, but protection was reversed with the re-introduction of mast cells to the ...
Cells were gated on CD45+ c-kit+ FcεRIα+ cells. Percentages of MCs among CD45+ cells are shown (Non-allergic, n = 3; Allergy, n = 10; OIT, n = 8). *P < 0.05, ** P < 0.01. d Serum mouse mast cell protease-1 (mMCPT1) concentrations were ...
(MRGPRX2) on MCs triggers cell activation and degranulation characterized by the release of cytoplasmic granule contents, including inflammatory mediators, into the extracellular space. This event leads to elevation of cytokines and the recruitment of immune cells, including CD45 + cells, ...