Interferometric scattering mass spectrometry allows spatiotemporally resolved measurement of a broad range of biomolecular interactions, one molecule at a time. 展开 关键词:BIOCHEM MOLEC BIOL DOI: 10.1126/science.aar5839 被引量: 2 年份: 2018
c) and the optical properties of the molecule and the nanochannel, defined by the total electric dipole polarizability (αt)24. The αt can be determined by the respective electric dipole polarizabilities of the biomolecule, αm, and of the nanochannel, ...
Although mass spectrometry is applied in many areas, the vast majority of small molecules lack experimental reference spectra. For over 70 years, spectrum prediction has remained a key challenge in the field. Existing deep learning methods do not leverage global structure in the molecule, potentially...
2 molecules RMM 30,000 + 1 molecule RMM 40,000 33,333 34,000 5 molecules RMM 10,000 + 1 molecule RMM 50,000 16,667 30,000 This simple example shows that M¯w/M¯n is smaller when the molecules are of similar size, that is, the distribution of sizes is small. The value of...
Mass Spectral libraries and databases provide the opportunity to automatically analyze large amounts of MSn data and identify many small molecule components, as well as transferring knowledge from research into more routine, quantitative applications. However, analysts...
Finally, the contents of the library are updated weekly to provide coverage of a wide chemical space, ensuring relevance to all small-molecule application areas. Example of the Mass Frontier software utilizing the contents of mzCloud...
For example, one molecule of nitric acid (HNO3) contains one nitrogen atom weighing 14.01 amu, one hydrogen atom weighing 1.008 amu, and three oxygen atoms weighing (3 × 16.00 amu) = 48.00 amu. The formula mass of nitric acid is therefore (14.01 amu + 1.008 amu + 48.00 amu) = 63.02...
Chain transfer stops the growth of a given molecular chain whilst passing the kinetic chain to a new molecule by reinitiating and forming a new active centre. In contrast, chain termination involves the interruption of both the molecular chain and the kinetic chain. The exact form of the ...
The quantification of membrane-associated biomolecular interactions is crucial to our understanding of various cellular processes. State-of-the-art single-molecule approaches rely largely on the addition of fluorescent labels, which complicates the quant
(i.e., 92.4 ± 0.8% lumenogenesis efficiency) (Fig.4q). This improved performance of 3D microcapsules could potentially be explained by the conformal encapsulation, which unlike microwells controls molecule transport via diffusion by locally preventing convection, therefore allowing for the more ...