for instance learning and memory. However, it is unclear whether RNA methylation plays a critical role in the pathophysiology of major depression disorder (MDD). Here, we report that expression of the fat mass and obesity associated gene (FTO), an RNA demethylase, is downregulated...
This also indicates that histone modifications are not always removed by erasers and may be removed through nucleosome turnover instead. This was recently demonstrated for the histone mark H3K79me19, a PTM catalyzed by DOT1L but without a known demethylase. Another example is replacement of ...
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