The isotopic distribution observed in mass spectra contains even more information than the mere charge number of an ion. The natural occurrence of isotopes differs between elements. Therefore, the relative inte
A case for in vivo mass-independent fractionation of mercury isotopes in fish[J].Geochemistry Geophysics and Geosystems 2009,10.Das R, Salters V J M, Odom A L. A case for in vivo mass- independent fractionation of mercury isotopes in fish[J]. Ge ochemistry, Geophysics, Geosystems, 2009,...
During the past decade mass spectrometry has undergone a number of significant changes that have far-reaching contributions especially in biology and medicine. The mass range of mass spectrometers has been extended by approximately an order of magnitude in the past decade. Certain types of mass ...
These TMT derivatives contain twice the number of heavy isotopes (+11 mass units) that are dispersed throughout the reporter and spacer regions (Figure 4). They are used as a mass offset for triggering peptide selection. The workflow for Super h...
Communications Earth & Environment volume 3, Article number: 82 (2022) Cite this article 5824 Accesses 6 Altmetric Metrics details Abstract Expanded ocean anoxia and global cooling have been invoked as major causal mechanisms for the Late Ordovician mass extinction, but the factors underpinning the ...
These TMT derivatives contain twice the number of heavy isotopes (+11 mass units) that are dispersed throughout the reporter and spacer regions (Figure 4). They are used as a mass offset for triggering peptide selection. The workflow for Super he...
number of targets, metabolic pathways and functions. Furthermore the magnitude of their effects is often much lower than that commonly observed for drugs. Recent research on vitamin E illustrates the limits of these approaches: tocopherols do not only have a vitamin function but they are also ...
Peak picking was performed using XCMS in an R environment22,23, annotation of isotopes, adducts, and artifacts was performed using the R package CAMERA24. Optimization of XCMS parameters was in accordance to a previously optimized strategy19. Peak picking and alignment parameters are summarized in ...
3B). A key advantage to this system is the very high mass resolution, which improves signal-to-noise and clearly distinguishes between isotopes with 1 amu mass difference. Detection limits for modified nucleosides are generally in the low-femtomole range. However, the system is prone to ...
Set number of microscans to 20 for both MS and MS/MS acquisition. 2.2.5. Set data-dependent mode for MS/MS acquisition to select the top 2 most abundantm/zonce in a 30s period prior to exclusion for 60s. Note: For improved sensitivity a precursor ionm/zlist can be included, which wi...