瘙痒是一种引起抓挠欲望的不适感觉,多种皮肤和神经系统疾病常伴有瘙痒发生。在许多情况下,抗组胺治疗对病理性瘙痒并不敏感。最近的研究已经确定了Mas相关GPCR(MRGPR)家族的成员,它们可被肥大细胞介质激活,促进非组胺依赖性瘙痒。Mr gprA3...
血管紧张素(1-7)_Mas的研究进展 万方数据
A 779 是一种G蛋白偶联受体Mas的有效拮抗剂。 产品性质 英文别名(English Synonym) A 779 中文名称(Chinese Name) / 靶点(Target) Angiotensin Receptor 通路(Pathway) GPCR/G Protein CAS号(CAS NO.) 159432-28-7 分子式(Formula) C39H60N12O11
1.3 Ang1-7 的MasR MasR作为Ang1-7的特异性受体,于1986年首次被描述为A类G蛋白偶联受体(GPCR)。由Mas原癌基因编码,能够转化和诱导NIH 3T3细胞中的病灶并促进裸鼠的致瘤性。MasR最初被认为是Ang II的受体。然而,通过对Mas信号传导的进一步...
Mas may form functional heterodimers with other GPCRs, such as AT 1 R and bradykinin receptors, and as such, Ang-(1-7) may negatively regulate Ang II through interactions between cognate receptors. Activation of Mas by Ang-(1-7) causes vasodilation, anti-inflammatory and antifibrotic effects,...
(GPCR) superfamily and was originally described as a protooncogene.Signaling via the Ang-(1-7) Mas receptor is still poorly elucidated however, evidence indicates that the receptor is coupled to a Gq/11 protein that activates phospholipase C (PLC).The Ang-(1-7) Mas receptor is expressed ...
MAS 相关 G 蛋白偶联受体成员 D,也被称为 MRGPRD,是由 MRGPRD 基因编码的蛋白质。它是一种 G 蛋白偶联受体(GPCR),属于在背根神经节(DRG)中表达的 Mas 相关 GPCR。它可调节伤害性感受器功能和/或发育, 包括疼痛的感觉或调节。它作为β-丙氨酸的特异性膜受体。与它相关的疾病包括股骨癌和 Fox-Fordyce 病。
(GPCR) superfamily and was originally described as a protooncogene.Signaling via the Ang-(1-7) Mas receptor is still poorly elucidated however, evidence indicates that the receptor is coupled to a Gq/11 protein that activates phospholipase C (PLC).The Ang-(1-7) Mas receptor is expressed ...
MAS1L (MAS1-like), also known as MAS-L or MRG (Mas-related G-protein coupled receptor MRG), is a 378 amino acid multi-pass membrane protein that belongs to the G-protein coupled receptor 1 (GPCR) family. MAS1 related proteins are thought to regulate nociceptor function and development,...
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