This invention provides reagents and methods for diagnosing renal disease. Differential levels of inosine metabolite, and proteins: apolipoprotein C-I, apolipoprotein C-II, fibrinogen alpha chain, or fibrinogen A-alpha chain, kininogen, Inter-Alpha Inhibitor H4 (ITIH4), keratin Type I cytoskeletol ...
2. Given the preventable nature of diabetic kidney disease (DKD), there is a need to identify individuals at risk of progression of DKD and ESKD for early intensive
Chronic kidney disease (CKD) is a common condition with an increasing prevalence. A number of comorbidities are associated with CKD and prognosis is poor, with many patients experiencing disease progression. Recognizing the factors associated with CKD progression enables high-risk patients to be ...
Combining the chronic kidney disease markers of creatinine-based estimated glomerular filtration rate and urine albumin-to-creatinine ratio with the biomarker cystatin C was associated with improved prediction of end-stage kidney disease and all-cause death, according to a study that will appear in th...
A meta-analysis of individual-level patient data from 66 clinical studies supports the utility of glomerular filtration rate as a surrogate endpoint in clinical trials for chronic kidney disease, with potential to enable detection of events earlier in the disease course. Lesley A. Inker , Willem ...
Introduction: Bone disorders in chronic kidney disease (CKD) are associated with heightened risks of fractures, vascular calcification, poor quality of life and mortality compared to the general population. However, diagnosis and management of these disorders in CKD are complex and appreciably limited ...
- 《Kidney International》 被引量: 719发表: 2005年 Inaccuracy of GFR predictions by plasma cystatin C in patients without kidney dysfunction and in advanced kidney disease. BACKGROUND: In clinical practice there is need for a simple and reliable test for determination of impaired renal function. ...
Diabetic kidney disease (DKD) is the leading cause of chronic kidney disease worldwide. Basement membranes (BMs) are ubiquitous extracellular matrices which are affected in many diseases including DKD. Here, the authors aimed to identify BM鈥恟elated markers in DKD and explored the immune cell inf...
The search for biomarkers associated with konzo disease has been a long-standing question within the research community. Here, the authors have uncovered a potential biomarker for konzo that is associated with the ability to manage oxidative damage. ...
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