Splenic marginal zone lymphoma (SMZL) is an indolent B cell malignancy usually involving spleen, bone marrow and blood. The disease presents as an incidental finding or with symptoms of splenic enlargement or anaemia. Diagnosis is based on a combination of lymphocyte morphology, immunophenotype and ...
BACKGROUND:A retrospective review and analysis of 275 patients with marginal zone lymphoma (MZL) was performed to determine prognostic factors. An effort was also made to establish a specific prognostic score for patients with extranodal MZL.METHODS:Patients were divided into 3 groups according to ...
Splenic marginal zone lymphoma (SMZL) is an indolent small B-cell lymphoma involving the spleen and bone marrow characterized by a micronodular tumoral infiltration that replaces the preexisting lymphoid follicles and shows marginal zone differentiation as a distinctive finding. ...
zone B-cell origin, and the neoplastic infiltrates are composed of a varying admixture of small lymphocytes, plasma cells, and lymphoplasmacytoids[6]. By definition, essentially no evidence of extracutaneous disease is found at the time of presentation with symptoms, and relevant studies have also...
Background: Splenic marginal zone lymphoma (SMZL) is a rare tumor without a uniform treatment approach. The authors describe a large population-based study evaluating survival outcomes of patients with SMZL according to the treatment received. Methods: From the Surveillance, Epidemiology, and End ...
Food and Drug Administration (FDA) granted Breakthrough Therapy Designation for Aliqopa™ (copanlisib) for the treatment of adult patients with relapsed marginal zone lymphoma (MZL) who have received at least two prior therapies. MZL is an...
be lim- ited to the interfollicular areas (IF) (2, 6), leading to potential diagnostic confusion with benign inter- follicular proliferations (5), and other neoplasms of small B-cells, such as marginal zone B-cell lym- phoma (9), mantle cell lymphoma (10), and follic- ular lymphoma....
What is marginal zone B-cell lymphoma?B-Cell Lymphoma:B-cells are a type of white blood cell found in the lymphatic system that plays a vital role in a person's adaptive immune system. B-cell lymphoma (which includes both non-Hodgkin's and Hodgkin's lymphoma) is a type of cancer in...
B symptoms 0.03 Hb ≤ 11 g/dL 0.02 — — Albumin ≤ 3.5 g/dL 0.02 EFS: event-free survival; OS: overall survival; MZL: marginal zone B-cell lymphoma; LDH: lactate dehydrogenase; Hb: hemoglobin; CR: complete response. Table 5. Prognostic Factors for Event-Free Survival and Ove...
Several recurrent translocations have been described in extranodal marginal zone lymphoma (MALT lymphoma), and their incidence varies with the anatomic site of disease. The t(11;18)(q21;q21) occurs mostly in gastric and pulmonary MALT lymphoma and results in BIRC3-MALT1 fusion.24 Detection is ...