Mapping targetable sites on human telomerase RNA pseudoknot/template domain using 2′-OMe RNA-interacting polynucleotide (RIPtide) microarrays. J. Biol. Chem. 2012; 287 :18843–18853.Gude, L, Berkovitch, S S, Santos, W L, Kutchukian, P S, Pawloski, A R, Kuimelis, R, McGall, G, ...
Extended Data Fig. 3 SNP effect onACEandAGT. a) The y-axis is the normalized expression ofACEin human kidney tubules (N = 356 samples), the x-axis is the PT cell fraction, each dot represents a single sample colored by their genotype C/C (red), C/T (green) and T/T (blue...
Glycoproteomics identified HOMER3 as a potentially targetable biomarker triggered by hypoxia and glucose deprivation in bladder cancer [17]. The glycoproteomics in high-grade serous ovarian carcinoma delineated three major clusters, showing a strong relationship between fucosylation and mesenchymal subtype, ...
Regulatory enhancer profiling of mesenchymal-type gastric cancer reveals subtype-specific epige- nomic landscapes and targetable vulnerabilities. Gut. 2023;72:226–41. 26. Dunham I, Kundaje A, Aldred SF, Collins PJ, Davis CA, Doyle F, et al. An integrated encyclopedia of DNA elements in the...
Furthermore, most somatic alterations that do exist are not currently targetable15,16—limiting the ability to identify an appropriate targeted therapy in most patients using traditional genome-guided precision medicine approaches. Nonetheless, chordoma tumor cells may have distinct genomic or functional ...
Liu, H. et al. Epigenomic and transcriptomic analyses define core cell types, genes and targetable mechanisms for kidney disease.Nat. Genet.54, 950–962 (2022). ArticleCASPubMedGoogle Scholar Pan-UKB team. Pan-ancestry genetic analysis of the UK Biobank.https://pan.ukbb.broadinstitute.org. ...
Precise genome-editing in human diseases: mechanisms, strategies and applications Yanjiang Zheng Yifei Li Yimin Hua Signal Transduction and Targeted Therapy(2024) Base editor-mediated large-scale screening of functional mutations in bacteria for industrial phenotypes ...
LanguageBrain Disorders: Affecting Brain Function, Structure and NeurochemistryBrain Plasticity, Cognitive Training and Mental States AssessmentBrain-Computer Interfaces for Human AugmentationBrain-Computer Interfaces: Current Trends and Novel ApplicationsCerebral Etiology and Treatment of the Gilles de la ...
The large datasets of PPIs generated by these approaches may reveal new host-virus interactions easily targetable by host-directed therapies on the basis of already existing small-molecule candidates. The so called "repurposing" or "repositioning" of pharmaceutical drugs and preclinical drugs, assisted...