Alongside efforts to identify somatically mutated cancer-dependency genes, a growing number of tumor-intrinsic cancer dependencies have been discovered via functional approaches whose classification extends beyond that of canonical mutated oncogenes1,4. These include dependencies reflecting synthetic lethal inter...
Funding: This work was primarily funded by grant ANR-09-RPDOC-007-01 to LL from the French Agence Nationale de la Recherche. AF was supported by a postdoctoral fellowship from the French Institut de Recherche Biome´dicale des Arme´es. The funders had no role in study d...
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D, RP-HPLC chromatogram depicting the separation of proteins present in the peak 1 using a shallower gradient of solvent B. The peak corresponding to TP1 and TP2 protein is indicated. A Coomassie-stained gel shows the separation of TP1 and TP2 in the fractions from the depicted peak. ...
(Ensembl: lncRNA; NCBI: pseudogene) and no known function, was highly and specifically expressed within the injury locus at 2 dpi.Gm10076expression was reduced but still localized to the injury site by 5 dpi and returned to baseline levels by 7 dpi.Rpph1, a ribozyme and component ...
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202 Tsai CM, Chang KT, Li L, Perng RP, Yang LY. Interrelationships between cellular nucleotide excision repair, cisplatin cytotoxicity, HER-2/neu gene expression, and epidermal growth factor receptor level in non-small cell lung cancer cells. Jpn J Cancer Res 2000; 91: 213–222. 203 Hsu ...
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Most triple negative breast cancers (TNBCs) are aggressively metastatic with a high degree of intra-tumoral heterogeneity (ITH), but how ITH contributes to metastasis is unclear. Here, clonal dynamics during metastasis were studied in vivo using two pati