The potential of RAS/RAF/MEK/ERK (MAPK) signaling pathway inhibitors in ovarian cancer: A systematic review and meta-analysis. Gynecol Oncol. 2023 Apr;171:83-94. doi: 10.1016/j.ygyno.2023.01.038. Epub 2023 Feb 24. PMID: 36841040. ^Farley J, Brady WE, Vathipadiekal V, Lankes HA, ...
最近,Nature Cell Biology刊登的题为Quantifying single-cell ERK dynamics in colorectal cancer organoids reveals EGFR as an amplifier of oncogenic MAPK pathway signaling的研究,作者团队通过 ERK 生物传感器 EKAREN5 监测结肠直肠癌 (CRC) 类器官中的单细胞 ERK 水平动态变化,揭示了有致癌突变的 MAPK 通路信号...
它们通常以由MAPK,MAPK激活剂(MEK,MKK或MAPK激酶)和MEK激活剂[MEK激酶(MEKK)]组成的三激酶结构组织。 Deviation from the strict control of MAPK signaling pathways has been implicated in the development of many human diseases including Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lat...
类器官、单细胞分析技术、MAPK信号通路｜MedChemExpress 听说“类器官”和“单细胞分析”技术比较火，小编也来凑个热闹。最近，Nature Cell Biology 刊登的题为 Quantifying single-cell ERK dynamics in colorectal cancer organoids reveals EGFR as an amplifier of oncogenic MAPK pathway signaling 的研究，作者团队...
et al. Identification of the JNK signaling pathway as a functional target of the tumor suppressor PTEN. Cancer Cell 11, 555–569 (2007). This paper shows that PTEN loss leads to AKT activation and to increased JNK activity in human cancer cell lines and clinical prostate samples. Article ...
最近,Nature Cell Biology 刊登的题为 Quantifying single-cell ERK dynamics in colorectal cancer organoids reveals EGFR as an amplifier of oncogenic MAPK pathway signaling 的研究,作者团队通过 ERK 生物传感器 EKAREN5 监测结肠直肠癌 (CRC) 类器官中的单细胞 ERK 水平动态变化,揭示了有致癌突变的 MAPK 通路...
Roberts, P.J. et al (2007) Targeting the Raf-MEK-ERK-mitogen activated protein kinase cascade for treatment of cancer.Oncogene 26(22): 3291-3310. Carracedo P. et al (2008) The PTEN-PI3K pathway: of feedbacks and cross-talks.Oncogene 27(41): 5527-5541. ...
最近,Nature Cell Biology刊登的题为Quantifying single-cell ERK dynamics in colorectal cancer organoids reveals EGFR as an amplifier of oncogenic MAPK pathway signaling的研究,作者团队通过 ERK 生物传感器 EKAREN5 监测结肠直肠癌 (CRC) 类器官中的单细胞 ERK 水平动态变化,揭示了有致癌突变的 MAPK 通路信号...
最近,Nature Cell Biology刊登的题为Quantifying single-cell ERK dynamics in colorectal cancer organoids reveals EGFR as an amplifier of oncogenic MAPK pathway signaling的研究,作者团队通过 ERK 生物传感器 EKAREN5 监测结肠直肠癌 (CRC) 类器官中的单细胞 ERK 水平动态变化,揭示了有致癌突变的 MAPK 通路信号...
Methods: Using the PubMed database, we searched for keywords, including "tumor", "cancer", "natural product", "phytochemistry", "plant chemical components", and "MAPK-signaling pathway". We also screened for compounds with well-defined structures that targeting the MAPK-...