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Structural variants are implicated in numerous diseases and make up the majority of varying nucleotides among human genomes. Here we describe an integrated set of eight structural variant classes comprising both balanced and unbalanced variants, which we
A partnership among 2 clinical and research centers of excellence at the University of Michigan, 3 practice-based research networks, and a clinical research center was created as the platform to support an NIH Roadmap. The result was a funded 3.3 million dollar, 3-year project supporting the ...
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University of Miami Miller School of Medicine, Gastroenterology, Miami, FL, USA Maria Abreu Unidad de Investigacion de Enfermedades Metabolicas, Instituto Nacional de Ciencias Medicas y Nutricion, Mexico City, Mexico Carlos A. Aguilar Salinas Peninsula College of Medicine and Dentistry, Exeter, UK Ta...
The goal of the International HapMap Project is to determine the common patterns of DNA sequence variation in the human genome and to make this information freely available in the public domain. An international consortium is developing a map of these pa
By characterizing the geographic and functional spectrum of human genetic variation, the 1000 Genomes Project aims to build a resource to help to understand the genetic contribution to disease. Here we describe the genomes of 1,092 individuals from 14 po
Michigan State University/Kalamazoo Center for Medical StudiesR. Anaya-PradoMichigan State University/Kalamazoo Center for Medical StudiesJournal of Investigative SurgeryLai, E.W.,Toledo-Pereyra, L.H.,Walsh, J.,Lopez-Neblina, F.,Anaya-Prado, R.The role of MAP kinases in trauma and ischemia-...
Sequence-based contact prediction has shown considerable promise in assisting non-homologous structure modeling, but it often requires many homologous sequences and a sufficient number of correct contacts to achieve correct folds. Here, we developed a me
Osteoarthritis causes pain and functional disability for over 500 million people worldwide. To develop disease-stratifying tools and modifying therapies, we need a better understanding of the molecular basis of the disease in relevant tissue and cell types. Here, we study primary cartilage and synoviu...