p38α MAP kinase is essential in lung stem and progenitor cell proliferation and differentiation. Nat Genet. 2007; 39 :750–8. [ PubMed ]Ventura JJ, Tenbaum S, Perdiguero E, Huth M, Guerra C, Barbacid M, Pasparakis M, Nebreda AR (2007) p38alpha MAP kinase is essential in lung ...
p38 alpha (MAP Kinase) Antibody 英文别名: p38 alpha (MAP Kinase) Antibody 中文名: 中文别名: CBNumber: CB05746921 分子式: 分子量: 0 MOL File: Mol file 化学性质安全信息用途供应商9 p38 alpha (MAP Kinase) Antibody化学性质 安全信息 p38 alpha (MAP Kinase) Antibody性质、用途与生产工艺 ...
The mitogen-activated protein kinase (MAPK) p38α is a key regulator in many cellular processes, whose activity is tightly regulated by upstream kinases, phosphatases and other regulators. Transforming growth factor-β activated kinase 1 (TAK1) is an upstream kinase in p38α signaling, and its f...
关键基因.RANKL与破骨细胞表面的RANK(receptor activator of NF-κB,核激活因子受体)结合后,刺激破骨细胞前体细胞向成熟破骨细胞分化,也刺激了成熟破骨细胞发挥骨吸收功能.在RANKL/RANK刺激破骨细胞前体细胞向成熟破骨细胞细胞分化的过程中,破骨细胞前体细胞中的P38 MAP Kinase(P38有丝分裂原激活蛋白激酶,P38 ...
Recent studies show that activation of p38 mitogen-activated protein kinase (MAPK) results in cancer cell apoptosis initiated by retinoids, cisplatin and other chemotherapeutic agents. The observation that divergent therapies act through a common signal transduction pathway raises the possibility of developi...
Modulation of behavioural responses by neuronal signalling pathways remains incompletely understood. Signalling via mitogen-activated protein (MAP) kinase cascades regulates multiple neuronal functions. Here, we show that neuronal p38α, a MAP kinase of the p38 kinase family, has a critical and specific...
www.nature.com/scientificreports OPEN received: 23 February 2016 accepted: 07 June 2016 Published: 29 June 2016 NMR Characterization of Information Flow and Allosteric Communities in the MAP Kinase p38γ Phillip C. Aoto, Bryan T. Martin & Peter E. Wright The intramolecular network ...
p38alpha MAP kinase as a sensor of reactive oxygen species in tumorigenesis. Cancer Cell. 2007;11:191-205.Dolado I,Swat A,Ajenjo N. p38alpha MAP kinase as a sensor of reactive oxygen species in tumorigenesis[J].Cancer Cell,2007,(02):191-205.doi:10.1016/j.ccr.2006.12.013....
Many protein kinase functions, including autophosphorylation in trans, require dimerization, possibly by activation segment exchange. Such dimers have been reported for a few autophosphorylating protein kinases, but not for mitogen-activated protein kinases (MAPKs). Activation of MAPKs proceeds not only...
Here, we report the effects of Rho-associated kinase (ROCK) and p38 MAP kinase on transforming growth factor (TGF)-β2-induced type I collagen production in human trabecular meshwork cells. TGF-β2 increased RhoA activity, actin polymerization, and myosin light chain 2 phosphorylation. These ...