Disease traitsHumanLinkage disequilibriumMappingSample sizeThe past decade has seen great improvements in biological and computational technology. These improvements have allowed for association mapping studies, which were previously restricted to small genomic regions, to be conducted on a genome-wide basis...
Afoodborne outbreakcan be defined as “an incident in which two or more people develop the same disease or infection following the consumption of a common contaminated food”. Most of the agents implicated in foodborne outbreaks are zoonotic agents*. The severity of the disease varies in humans,...
In humans, infections caused by L. monocytogenes (“listeriosis”) can be more or less severe depending on whether they are caused by invasive or non-invasive forms of the disease. Non-invasive infections may be asymptomatic (symptom-free) or cause mild flu-like symptoms and diarrhoea. This ...
"These patterns suggest that the search for microbial factors associated with disease, although difficult to ascertain due to the high intrinsic levels of variability among healthy individuals, may be achieved using broad profiling techniques such as those employed here," the authors wrote in Science...
Within the non-coding genome, constrained regions are enriched for known regulatory elements and variants that are implicated in complex human diseases and traits, facilitating the triangulation of biological annotation, disease association and natural selection to non-coding DNA analysis. More constrained...
The HapMap project has taken advantage of this pattern of recombination and is characterising the haplotype structure of the entire human genome, primarily to aid genome-wide association studies of complex, common disease. HapMap has also provided atool for population geneticists to investigate genome...
Reich's plan is to find ancient DNA from every culture known to archaeology in the world. Ultimately, he hopes to build a genetic atlas of humanity over the past 50…
Climate disasters can also alter human behavior patterns in ways that increase their chances of being exposed to pathogens. For example, during heat waves, people often spend more time in water, which can lead to an increase in waterborne disease outbreaks. ...
Linkage disequilibrium in humans: models and data. Am. J. Hum. Genet. 69, 1–14 (2001) CAS PubMed PubMed Central Google Scholar Jorde, L. B. Linkage disequilibrium and the search for complex disease genes. Genome Res. 10, 1435–1444 (2000) CAS PubMed Google Scholar Reich, D. E...
OtherCampylobacterspecies, seldom pathogenic for humans, have been associated with disease in animals. Among these,C.fetussubsp. venerealisis associated with infertility in cattle and abortion in sheep, goats and cattle.C.fetussubsp.fetusare linked to septic abortion and mastitis, in sheep, goats, ...