In 1993, scientist Hans Brunner discovered that several male members of a large Dutch family who exhibited behaviors such as impulsive aggression, arson, and attempted rape possessed a mutant copy of the MAOA gene, the gene that codes for the production of the enzyme monoamine oxidase A ("MAO...
In 1993, scientist Hans Brunner discovered that several male members of a large Dutch family who exhibited behaviors such as impulsive aggression, arson, and attempted rape possessed a mutant copy of the MAOA gene, the gene that codes for the production of the enzyme monoamine oxidase A ("MAO...
In a seminal article, Brunner and colleagues (1) discovered a stop codon unique to one Dutch family leading to altered metabolism of monoamine neurotransmitters and antisocial behavior in hemizygous males (Figure 1). Discovery of this rare functional variant was followed by the detection of a ...
Deficiency in monoamine oxidase A (MAOA), an enzyme that degrades serotonin and norepinephrine, has recently been shown to be associated with aggressive behavior in men of a Dutch family. A line of transgenic mice was isolated in which transgene integration caused a deletion in the gene ...