Although the N-linked glycan profiles of human sera are different from mouse sera, the high-mannose type N-linked glycans were elevated with cancer in both cases. In addition, one high-mannose type glycan Man9, m/z 1905.630, was found to increase significantly with cancer for both human ...
In contrast to yeast, however, mucin-type O-GalNAc glycosylation became the most common covalent modification of Ser and Thr residues in mammals. Analysis of orthologs proteins from yeast and human revealed a set of common substrates, and glycodomain classification and sequence alignments showed a ...
Histoscores were split into high and low expression using the ROC curve analysis for each tumour type. log-rank analysis (two-sided) was used to compare PMI and cancer-specific survival using SPSS (version 22). e, Mean weight of 28 mice during treatment with AOM and DSS, with or without...
(bnAbs) that target this shield have been isolated. The unusually high glycan density on the gp120 subunit limits processing during biosynthesis, leaving a region of under-processed oligomannose-type structures, which is a primary target of these bnAbs. Here we investigate the contribution of ...
3A), which uses a 18O-labeling technique and specific endoglycosidases to introduce mass signatures to distinguish N-glycan types and to quantify each site’s occupancy30. These analyses demonstrate that most of the sites are either fully or highly glycosylated with complex-type N-glycans, and ...
Glycan biosynthesis is elaborative, multi-compartmental and involves many glycosyltransferases. Failure to assemble N-glycans leads to phenotypic changes developing infection, cancer, congenital disorders of glycosylation (CDGs) among others. Biosynthesis of N-glycans begins at the endoplasmic reticulum (ER...
These end other Michael or Michael-type acceptors and adducts are shown to influence the replication, differentiation or maturation of blood c... TP Kogan,TC Somers - US 被引量: 79发表: 1995年 Plasma proteomic profiles of bovine growth hormone transgenic mice as they age Attenuation of the ...
Dolichol-phosphate mannose (DPM) synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose... H Ashida,Y Maeda,T Kinoshita - 《Journal of Biological Chemistry》 被引量: 193发表: 2006年 Dolichol-phosphate mannose synthase: Structure,...
type glycoforms with no terminal mannosyl residues. Ovomucoid, another glycoprotein from hen egg white, contains a trimannosylpentasaccharidechain, and othercomplex sugar chains[61,62]. It has at least 12 kinds of glycans, and only one of them is a high-mannose-type glycan with a trimannosyl...
(unit-less) but comparable values, n = 19 3D structures, *** denotes p < 0.001 using paired two-tailed type 2 Student's t-tests), see supplemental Table S3 for more details and ii) the degree of N-glycan core fucosylation (in %) of the individual HNE N-glycosylation sites based on...