2006. High-mannose-type glycan modi- fications of dihydrofolate reductase using glycan-methotrexate conjugates. Bioorg Med Chem. 14:5220-5229.K. Totani, I. Matsuo, Y. Ihara, Y. Ito, High-mannose-type glycan modifications of dihydrofolate reductase using glycanemethotrexate conjugates, Bioorg. Med...
A comprehensive method for the construction of a high-mannose-type glycan library by systematic chemo-enzymatic trimming of a single Man9-based precursor was developed. It consists of the chemical synthesis of a non-natural tridecasaccharide precursor, the orthogonal demasking of the non-reducing ...
2). These substrates originate from the incomplete catabolism of high-mannose and hybrid-type glycans. High-mannose type oligomannosides are normally poorly present on mature glycoproteins but are found on newly synthesized glycoproteins undergoing the glycan biosynthetic trimming inside rough endoplasmic ...
High-Mannose Glycan-Dependent Epitopes Are Frequently Targeted in Broad Neutralizing Antibody Responses during Human Immunodeficiency Virus Type 1 Infection An abstract of the article "High-Mannose Glycan-Dependent Epitopes Are Frequently Targeted in Broad Neutralizing Antibody Responses during Human ...
The high-mannose-type N-glycan attached in yeast blocks the taste-modifying activity of rMCL. The bulky N-glycan attached to Asn42 may cause steric hindrance in the interaction between active residues and the sweet taste receptor hT1R2/hT1R3. 展开 ...
(bnAbs) that target this shield have been isolated. The unusually high glycan density on the gp120 subunit limits processing during biosynthesis, leaving a region of under-processed oligomannose-type structures, which is a primary target of these bnAbs. Here we investigate the contribution of ...
E - cadherin, as a cell adhesion molecule containing high mannose type N - linked glycan, mediates homotypic cell adhesion. E - 钙粘蛋白作为含有高甘露糖型N - 糖链的细胞粘附分子, 介导着细胞间的嗜同性粘附. 来自互联网 8. Mannose binding protein ( MBP ), is a member of C type collectin ...
机译:合成了HIV糖蛋白gp120的高甘露糖聚糖亚结构的寡糖Man_4和Man_5,其末端带有1-硫代甘露聚糖残基。通过与二氯甲烷反应并用叠氮化钠置换,可以将异头硫醇容易地转化为叠氮甲基糖苷配基。然后利用硫醇烷基化或最小长度的叠氮化物/炔烃反应性束缚剂将所得的寡甘露聚糖缀合至泛素。通过结合高效的偶联反应和短链,我们寻...
Coffee beans, fenugreek and guar gums are rich sources of galactomannans [4], but these plant polysaccharides are not degraded in the mammalian GI tract and, therefore, provide very little bio-available mannose for glycan synthesis. These polysaccharides are partially digested by anaerobic bacteria ...
Although the N-linked glycan profiles of human sera are different from mouse sera, the high-mannose type N-linked glycans were elevated with cancer in both cases. In addition, one high-mannose type glycan Man9, m/z 1905.630, was found to increase significantly with cancer for both human ...