甘露糖结合凝集素缺乏症基因检测是对英文为Mannose-binding lectin deficiency的疾病不同类型进行基因检测的总称,该病又称为甘露糖结合凝集素蛋白缺乏症,甘露糖结合蛋白缺乏症,MBL缺乏症,MBL2缺乏症,MBP缺乏症。该病是由于基因突变引起的功能蛋白减少引起的,基因解码已明确其发病原因,可以通过基因检测排除和验证发报道过...
mannose binding lectin deficiencyInnate immunity consists of macrophages, neutrophils, natural killer cells, mucosal immunuglobulins and the comlement system. Mannose binding lectin (MBL) takes part in innate immunity through opsonisation and complement activation. MBL deficiency is associated with some ...
Mannose-Binding Lectin / MBL Pathway Deficiency Background Mannose-binding lectin (MBL), also called mannose-binding protein (MBP), is structurally similar to C1q. It binds multiple bacterial monosaccharides (mannose, N-acetylglucosamine, N-acetylmannosamine, and L-fucose) and activates associated se...
Piezzi, T. Klima et al., "Impact of mannose- binding lectin deficiency on radiocontrast-induced renal dys- function: a post-hoc analysis of a multicenter randomized controlled trial," BMC Nephrology, vol. 13, p. 99, 2012.Osthoff M, Piezzi V, Klima T, Christ A, Marana I, Hartwiger...
Mannose-binding lectin (MBL) deficiency has now been recognised for 15 years. Numerous studies have shown that MBL deficiency is associated with an increased susceptibility to a range of infections. However, the importance of MBL, in defence against infection, is still debated. This article discuss...
Klein, "Deficiency of mannose-binding lectin and burden of infection in children with malignancy: a prospective study," The Lancet, vol. HBV Viral Load and Liver Enzyme Levels May Be Associated with the Wild MBL2 AA Genotype Saraheimo et al., "Association between mannose-binding lectin, high...
Structure of a C-type mannose-binding protein complexed with an oligosaccharide. Nature. 1992;360(6400):127–34.10.1038/360127a0Search in Google Scholar PubMed [14] Thiel S, Frederiksen PD, Jensenius JC. Clinical manifestations of mannan-binding lectin deficiency. Mol Immunol. 2006;43(1–2)...
Molecular and Cellular Biochemistry (2021) 476:2917–2942 https://doi.org/10.1007/s11010-021-04107-3 Status of mannose‑binding lectin (MBL) and complement system in COVID‑19 patients and therapeutic applications of antiviral plant MBLs Anita Gupta1 · G. S. ...
High prevalence of genetically-determined mannose binding lectin deficiency in young children with invasive pneumococcal disease. High prevalence of genetically-determined mannose binding lectin deficiency in young children with invasive pneumococcal disease. Clin. Microbiol. Infect. 2014;... C Mu?Oz-...
Deficiency of mannose-binding lectin (MBL), a recognition molecule of the lectin pathway of complement, is associated with increased susceptibility to infections. The high frequency of MBL deficiency suggests that defective MBL-mediated innate immunity can be compensated by alternative defense strategies....