Ferroptosis is an iron-dependent cell death characterized by the accumulation of hydroperoxided phospholipids. Here, we report that the NUPR1 inhibitor ZZW-115 induces ROS accumulation followed by a ferroptotic cell death, which could be prevented by ferrostatin-1 (Fer-1) and ROS-scavenging agents...
Aging markedly increases cancer risk, yet our mechanistic understanding of how aging influences cancer initiation is limited. Here we demonstrate that the loss of ZNRF3, an inhibitor of Wnt signaling that is frequently mutated in adrenocortical carcinoma
Lung infections caused by Streptococcus pneumonia are a global leading cause of death. The reactive oxygen species H2O2 is one of the virulence factors of Streptococcus pneumoniae. The Golgi apparatus is essential for the inflammatory response of a eukar
Recent studies have identified abnormal m6A regulation as a key factor in the progression of various cancers. For example, m6A hypomethylation inhibits the degradation of FGFR4 mRNA, upregulates FGFR4 expression, and ultimately leads to activation of the β-catenin/TCF4 signaling pathway, transmitting...
However, drug resistance in cancer limits the lethal effect of cisplatin on tumors [4, 6]. Therefore, this study aims to explore the new mechanism of cisplatin resistance from the perspective of cell death, with a view to developing more effective therapies. PANoptosis is a new type of ...
We show that genetic disruption of GABPβ1L (β1L), a tetramer-forming isoform of GABP that is dispensable for normal development, results in TERT silencing in a TERT promoter mutation-dependent manner. Reducing TERT expression by disrupting β1L culminates in telomere loss and cell death ...
- Cell Death & Disease 被引量: 0 (R,S)‐α‐Amino‐3‐Hydroxy‐5‐Methylisoxazole‐4‐Propionic Acid (AMPA) Receptors Mediate a Calcium‐Dependent Inhibition of the Metabotropic Glutamate ... a selective agonist for the metabotropic glutamate receptor, stimulated the formation of inositol 1,4...
Astaxanthin (AXT) is a keto-carotenoid with a variety of biological functions, including antioxidant and anti-inflammatory effects This study aimed to explore the protective role and underlying mechanism of AXT in the pathogenesis of COPD. In this study, we found AXT alleviated pulmonary emphysema ...
However, the functional mechanism underlying the tumor suppressive function of AATK in respect to its kinase activity has not been analyzed in detail. AATK belongs to the LMTK family of kinases. To date, only LMTK2 has been identified as Ser/Thr kinase [19]. Based on homology, AATK has ...
Myocardial infarction (MI), one of the most severe types of heart attack, exerts a strong negative effect on heart muscle by causing a massive and rapid loss of cardiomyocytes. However, the existing therapies do little to improve cardiac regeneration. Du